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CAS RN: 738-70-5 | Product Number: T2286

Trimethoprim


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
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25G
€119.00
3   ≥20 
100G
€107.00
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500G
€267.00
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Product Number T2286
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__4H__1__8N__4O__3 = 290.32  
Physical State (20 deg.C) Solid
CAS RN 738-70-5
Reaxys Registry Number 625127
PubChem Substance ID 87558288
Merck Index (14) 9709
Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 199.0 to 205.0 °C
Solubility in hot Methanol almost transparency
Properties (reference)
Melting Point 202 °C
Solubility in water Insoluble
Degree of solubility in water 400 mg/l   25 °C
Solubility (slightly sol. in) Methanol,Chloroform
Solubility (insoluble in) Ether,Benzene
GHS
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 212-006-2
RTECS# UV8225000
Transport Information:
HS Number 2933599590
Application
Trimethoprim: A Synthetic Antibiotic Agent Inhibiting Dihydrofolate Reductase

Trimethoprim, a synthetic antibiotic agent, exerts antimicrobial activity by blocking the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. In addition, some combination agents with the other antimicrobials (e.g.: sulphamethoxazole [S0361], daptomycin [D4229] and polymyxin B [P1923]) are widely used for the treatment of infections including MRSA infection. (The product is for research purpose only.)

References


PubMed Literature


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