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CAS RN: 15318-45-3 | Product Number: T2802

Thiamphenicol


Purity: >98.0%(HPLC)(N)
Synonyms:
  • 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-[4-(methylsulfonyl)phenyl]-2-propyl]acetamide
Documents:
5G
€43.00
2   11  
25G
€142.00
2   17  

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Product Number T2802
Purity / Analysis Method >98.0%(HPLC)(N)
Molecular Formula / Molecular Weight C__1__2H__1__5Cl__2NO__5S = 356.21  
Physical State (20 deg.C) Solid
CAS RN 15318-45-3
Reaxys Registry Number 2819542
PubChem Substance ID 135726881
Merck Index (14) 9301
MDL Number

MFCD00467983

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(with Total Nitrogen) min. 98.0 %
Melting point 164.0 to 168.0 °C
Specific rotation [a]20/D +10.0 to +13.0 deg(C=1, EtOH)
Properties (reference)
Melting Point 166 °C
Specific Rotation 11° (C=1,EtOH)
Solubility (soluble in) Ethanol
GHS
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 239-355-3
RTECS# AB6680000
Transport Information:
HS Number 2941400000
Application
Thiamphenicol: A More Potent and Less Toxic Derivative of Chloramphenicol [C2255]

Thiamphenicol was a semi-synthetic chloramphenicol at first in which the nitro moiety of chloramphenicol [C2255] was replaced by a methylsulphone. Thiamphenicol can now be made by total chemical synthesis. Thiamphenicol has broad activity against Gram-positive and Gram-negative aerobes and for some anaerobes. Thiamphenicol has a similar spectrum of activity to that of chloramphenicol, but is more potent and less toxic. Thiamphenicol inhibits protein synthesis in susceptible organisms by binding to specific nucleotides in 23S rRNA within the 50S subunit of a bacterial ribosome.

References


PubMed Literature


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