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CAS RN: 24356-66-9 | Product Number: V0098

Vidarabine Monohydrate


Purity: >98.0%(T)(HPLC)
Synonyms:
  • Adenine 9-β-D-Arabinofuranoside Monohydrate
  • Ara-A Monohydrate
  • 9-(β-D-Arabinofuranosyl)adenine Monohydrate
Documents:
1G
€92.00
1   ≥20 
5G
€319.00
3   ≥20 

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Product Number V0098
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__3N__5O__4·H__2O = 285.27  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
CAS RN 24356-66-9
Related CAS RN 5536-17-4
Reaxys Registry Number 93029
PubChem Substance ID 87560128
Merck Index (14) 9976
MDL Number

MFCD00065471

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %(calcd.on dried substance)
Specific rotation [a]20/D -2.0 to -4.0 deg(C=1, DMF)
Drying loss 5.0 to 7.0 %
Properties (reference)
Melting Point 253 °C
Specific Rotation -3° (C=1,DMF)
Solubility (soluble in) Dimethylformamide
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws: / Compliance with laws, Regulations
RTECS# AU6200000
Transport Information:
HS Number 2940000080
Application
Vidarabine: An Arabinosyladenine with Ant-Virus and Anti-Cancer Activities

Vidarabine (arabinosyladenine, ara-A) is a synthetic purine nucleoside, and was first synthesized by Lee et al. in 1960. Vidarabine was originally intended as an anti-cancer agent, while the anti-viral activity against herpesvirus and vaccinia virus was reported by Rudder et al. in 1965. And also the activity against varicella-zoster virus was reported by Miller et al. in 1968. Vidarabine had a broad-spectrum activity against DNA viruses but little activity against RNA viruses. Vidarabine is converted to the active form vidarabine triphosphate (ara-ATP) which inhibits viral DNA polymerase activity in vitro and in vivo.

References


PubMed Literature


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