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CAS RN: 19545-26-7 | Product Number: W0007

Wortmannin


Purity: >98.0%(HPLC)
Synonyms:
Documents:
20MG
€59.00
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Product Number W0007
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__3H__2__4O__8 = 428.44  
Physical State (20 deg.C) Solid
Storage Temperature -20°C
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 19545-26-7
Reaxys Registry Number 67676
PubChem Substance ID 253659701
Merck Index (14) 10053
MDL Number

MFCD00133927

Specifications
Appearance White to Yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 235.0 to 239.0 °C
Specific rotation +85.0 to +89.0 deg(C=0.17,CHCl3)
Properties (reference)
Melting Point 237 °C
Maximum Absorption Wavelength 296 nm
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 + H310 + H330 : Fatal if swallowed, in contact with skin or if inhaled.
Precautionary Statements P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P262 : Do not get in eyes, on skin, or on clothing.
P280 : Wear protective gloves/ protective clothing.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P302 + P352 + P310 : IF ON SKIN: Wash with plenty of water. Immediately call a POISON CENTER/doctor.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P403 + P233 : Store in a well-ventilated place. Keep container tightly closed.
Related Laws: / Compliance with laws, Regulations
RTECS# CB9641000
Transport Information:
UN Number UN3462
Class 6.1
Packing Group I
HS Number 2932209090
Application
Studies of Phosphatidylinositol 3-Kinase (PI3K) Inhibition by Wortmannin
References

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes.

T. Okada, Y. Kawano, T. Sakakibara, O. Hazeki, M. Ui, J. Biol. Chem. 1994, 269, 3568.

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses

A. Arcaro, M. P. Wymann, Biochem. J. 1993, 296, 297.

Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine

E. H. Walker, M. E. Pacold, O. Perisic, L. Stephens, P. T. Hawkins, M. P. Wymann, R. L. Williams, Mol. Cell 2000, 6, 909.

Targeting the PI3K-Akt pathway in human cancer: Rationale and promise

Ji Luo, B. D. Manning, L. C. Cantley, Cancer Cell 2003, 4, 257.


Application
PI3K Inhibitor
References

1)Historical landmarks of autophagy research

Y. Ohsumi, Cell Res. 2014, 24, 9.

2)Autophagy: renovation of cells and tissues

N. Mizushima, M. Komatsu, Cell 2011, 147, 728.

3)Regulation of autophagy by kinases

S. Sridharan, K. Jain, A. Basu, Cancers 2011, 3, 2630.

4)Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

A. Kihara, T. Noda, N. Ishihara, Y. Ohsumi, J. Cell Biol. 2001, 152, 519.

5)Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

A. Kihara, Y. Kabeya, Y. Ohsumi, T. Yoshimori, EMBO Rep. 2001, 2, 330.

6)Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

A. Arcaro, M. P. Wymann, Biochem. J. 1993, 296, 297.

7)The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

E. F. C. Blommaart, U. Krause, J. P. M. Schellens, H. Vreeling-Sindelárová, A. J. Meijer, Eur. J. Biochem. 1997, 243, 240.

8)Variation in the safety of induced pluripotent stem cell lines

K. Miura, Y. Okada, T. Aoi, A. Okada, K. Takahashi, K. Okita, M. Nakagawa, M. Koyanagi, K. Tanabe, M. Ohnuki, D. Ogawa, E. Ikeda, H. Okano, S. Yamanaka, Nat. Biotechnol. 2009, 27, 743.

9)PI3K/AKT signaling pathway is essential for survival of induced pluripotent stem cells

A. M. Hossini, A. S. Quast, M. Plötz, K. Grauel, T. Exner, J. Küchler, H. Stachelscheid, J. Eberle, A. Rabien, E. Makrantonaki, C. C. Zouboulis, PLoS ONE 2016, 11, e0154770.


PubMed Literature


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