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Published TCIMAIL newest issue No.199
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CAS RN: 512-04-9 | Product Number: D1474
Diosgenin
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Purity: >95.0%(GC)
Synonyms:
- Nitogenin
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€16.00
|
1 | ≥40 |
|
| 10G |
€77.00
|
4 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D1474 |
Purity / Analysis Method 
|
>95.0%(GC) |
| Molecular Formula / Molecular Weight | C__2__7H__4__2O__3 = 414.63 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 512-04-9 |
| PubChem Substance ID | 87567972 |
| SDBS (AIST Spectral DB) | 11108 |
| Merck Index (14) | 3295 |
| MDL Number | MFCD00016887 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| Melting point | 205.0 to 208.0 °C |
| Specific rotation [a]20/D | -123 to -127 deg(C=1, CHCL3) |
Properties (reference)
| Melting Point | 205 °C |
| Specific Rotation | -126° (C=1,CHCl3) |
GHS
Related Laws:
| EC Number | 208-134-3 |
| RTECS# | WH1450000 |
Transport Information:
| HS Number | 2932990048 |
Application
Diosgenin: A Steroid Sapogenin with Multiple Biological and Pharmacological Activities
Diosgenin is a naturally occurring steroid sapogenin found abundantly in legumes and yams. Diosgenin is often used a precursor of various synthetic steroidal agents.1) On the other hand, it has been reported that diosgenin has multiple biological and pharmacological activities, including anticancer, cardiovascular protective, anti-diabetes, neuroprotective, immunomodulatory, estrogenic, and skin protective effects.2,3) In addition, recently diosgenin has been demonstrated to improve memory and reduced axonal degeneration in an Alzheimer's disease mouse model.4,5) (The product is for research purpose only.)
References
- 1) Steroid research at Syntex: “the Pill” and cortisone (a review)
- 2) Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin (a review)
- 3) A review on pharmacological and analytical aspects of diosgenin: a concise report (a review)
- 4) Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice
- 5) Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS.
PubMed Literature
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