Published TCIMAIL newest issue No.196
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SSEAs (Stage-specific embryonic antigens)
Stage-Specific Embryonic Antigens (SSEAs) are glycan antigens known to vary in their expression levels across the stages of embryonic development and cell differentiation.1)
SSEA-1, also called Lewis X Antigen, is expressed on the surface of mouse embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) and is often used as a mouse pluripotent stem cell marker. SSEA-3 and SSEA-4 are the Globo-series Glycosphingolipids Gb5 and SialylGb5, and are localized on the cell surface of human embryonic cancer cells (EC cells), ES cells, iPS cells and Muse (Multilineage-differentiating Stress Enduring) cells, where they are used as markers. SSEA-4 has also been shown to be overexpressed in many cancers, suggesting a correlation with disease progression.2)
TCI has a wide line-up of mouse monoclonal antibodies, synthetic glycans and glycan conjugates for SSEA-3, SSEA-4, SSEA-1.
Products
Binding specificity of A3729 and A3742
Binding specificity of A2578
Related Products
SSEA-3 (Gb5)-related Products
SSEA-4 (SialylGb5)-related Products
SSEA-1 (Lewis X)-related Products
Globo-series Glycolipids-related Products
Product Brochure
References
- 1) Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage-Specific Embryonic Antigens
- 2) Expression of stage-specific embryonic antigen-4 (SSEA-4) defines spontaneous loss of epithelial phenotype in human solid tumor cells