Sisomicin Sulfate: An Aminoglycoside Antibiotic that is Effective against Pseudomonas aeruginosa
Sisomicin sulfate is a naturally occurring aminoglycoside antibiotic produced by
Micromonospora inyoensis. Sisomicin is bactericidal in action against a wide range of Gram-negative and Gram-positive bacteria, including
Klebsiella species,
Escherichia coli,
Pseudomonas aeruginosa,
Enterobacter species, and
Proteus species. Sisomicin is closely related structurally to gentamicin [
G0383], but
in vitro studies have shown it to have superior activity to gentamicin against
Pseudomonas aeruginosa. Sisomicin, like that of the other aminoglycoside antibiotics, binds the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of transcription. Consequently, bacterial protein synthesis is inhibited. (The product is for research purpose only.)