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CAS RN: 183499-56-1 | Product Number: L0337

L-778123 Dihydrochloride

Purity: >98.0%(HPLC)
  • 4-[[5-[[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]benzonitrile Dihydrochloride
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Product Number L0337
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__2H__2__0ClN__5O·2HCl = 478.8  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 183499-56-1
Reaxys Registry Number 13856100
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 13.20 to 15.40 %
Chloride 14.1 to 15.4 %
Properties (reference)
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell.
P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.
Related Laws:
Transport Information:
HS Number 2933599590
L-778123: A Dual Inhibitor of FTase and GGTase-I

L-778123 is a dual inhibitor of farnesyl protein transferase (FTase) and geranylgeranyl protein transferase type-I (GGTase-I). Ras is a family of related proteins that control growth, differentiation, and transformation. Oncogenic Ras requires the farnesylation by FTase or GGTase-I for the cell-transforming activity of oncogenic mutants. Therefore, FTase and GGTase-I inhibitors have received attention in recent years, as a new class of potential cancer therapeutic agents. (The product is for research purpose only.)


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