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Published TCIMAIL newest issue No.201
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CAS RN: 114289-47-3 | Product Number: C4099
CI 976
×
Purity: >95.0%(HPLC)
Synonyms:
- PD 128042
- 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 20MG |
120,00 €
|
Contact Us | 19 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | C4099 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__9NO__4 = 393.57 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 114289-47-3 |
| Reaxys Registry Number | 5831010 |
| MDL Number | MFCD00869662 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Melting point | 58.0 to 62.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 60 °C |
GHS
Related Laws:
| RTECS# | JR2052000 |
Transport Information:
| HS Number | 2924297099 |
Application
Cl-976: An Orally Active and Selective Inhibitor of Acyl-Coenzyme A (ACAT)
CI-976 is an orally active and selective inhibitor of Acyl-Coenzyme A (ACAT, also known as sterol O-acyltransferase or SOAT), which is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-CoA.1) Recently, many studies have suggested that ACAT-1 (SOAT-1) plays a critical role in cancer initiation and progression and is an attractive target for novel anticancer therapies.2,3) For this reason, the inhibitor CI-976 is being used in cancer research. (The product is for research use only.)
References
- 1) In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT
- 2) Cholesterol metabolism: New functions and therapeutic approaches in cancer (a review)
- 3) Targeting Sterol O-Acyltransferase/Acyl-CoA: Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential (a review)
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