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CAS RN: 50924-49-7 | Product Number: M2399

Mizoribine


Purity: >98.0%(HPLC)
Synonyms:
  • 1-(β-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide
Documents:
50MG
€87.00
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250MG
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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number M2399
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__9H__1__3N__3O__6 = 259.22  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 50924-49-7
Reaxys Registry Number 8155135
PubChem Substance ID 253659680
Merck Index (14) 6222
MDL Number

MFCD00057221

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Elemental analysis(Nitrogen) 15.50 to 16.70 %
Specific rotation [a]20/D -25.0 to -27.0 deg(C=2,H2O)
Properties (reference)
Melting Point 198 °C(dec.)
Specific Rotation -26° (C=2,H2O)
Maximum Absorption Wavelength 280 nm
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H360 : May damage fertility or the unborn child.
H340 : May cause genetic defects.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
Related Laws:
RTECS# NI3980000
Transport Information:
HS Number 2940000080
Application
Mizoribine: An Imidazole Nucleoside Immunosuppressive and Antiviral Agent

Mizoribine (bredinin, MZR), an imidazole nucleoside, is an immunosuppressive and an antiviral agent. The immunosuppressive effect of mizoribine has been reported to be due to the inhibition of de novo guanosine synthesis, via inhibition of inosine-5'-monophosphate dehydrogenase (IMPDH).1-4) On the other hand, the combination of mizoribine and interferon (IFN)-α have been reported to show antiviral activities. The mechanisms of action would appear that mizoribine inhibits virus RNA replication based on the depletion of the intracellular pool of guanosine nucleotides by IMPDH inhibition.5-7) In addition, mizoribine has been reported to its anti-coronavirus activity.8) (The product is for research purpose only.)

References


PubMed Literature


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