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Trifluoromethylthiolation [Synthetic Reagents]

 The trifluoromethylthio group (CF3S-) has attracted attention as a potentially-significant functional group in the pharmaceutical and agrochemical fields because of its strong electron-withdrawing effect and high lipophilicity. Some methods for direct trifluoromethylthiolation have been developed and one of them, copper(I) trifluoromethanethiolate (CuSCF3) [C1159] is an effective nucleophilic trifluoromethylthiolating reagent. On the other hand, a simple electrophilic reagent, trifluoromethylsulphenyl chloride (CF3SCl) is gaseous and highly toxic, so it is hardly used now.
 Recently, some electrophilic trifluoromethylthiolating reagents which are safer to use and easier to handle, have been reported. Both N-Methyl-N-(trifluoromethylthio)aniline [M2595]1) developed by Billard et al. and N-(trifluoromethylthio)phthalimide [T3143]2) developed by Rueping are useful electrophilic trifluoromethylthiolating reagents because their states are liquid and solid respectively. In addition, Shibata et al. have developed a hypervalent iodonium ylide having a trifluoromethanesulfonyl group [P2143], and used it for the electrophilic trifluoromethylthiolation. In this reaction, it seems that the trifluoromethylthiocation species generated in situ by the reduction of P2143 acts as an electrophilic trifluoromethylthiolating reagent for enamines, indoles and β-ketoesters.3)
6 Results Found
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Product Number T3143
CAS RN 719-98-2
Purity / Analysis Method: >98.0%(GC)

Product Number S0977
CAS RN 811-68-7
Purity / Analysis Method: >95.0%(T)

Product Number M2595
CAS RN 66476-44-6
Purity / Analysis Method: >98.0%(GC)

Product Number M2782
CAS RN 1045822-31-8
Purity / Analysis Method: >98.0%(GC)(N)

Product Number C1159
CAS RN 3872-23-9
Purity / Analysis Method: >90.0%(T)

Product Number P2143
CAS RN 1443036-49-4
Purity / Analysis Method: >98.0%(HPLC)

Product Number:   T3143 | Purity / Analysis Method:   >98.0%(GC)

Product Number:   S0977 | Purity / Analysis Method:   >95.0%(T)

Product Number:   M2595 | Purity / Analysis Method:   >98.0%(GC)

Product Number:   M2782 | Purity / Analysis Method:   >98.0%(GC)(N)

Product Number:   C1159 | Purity / Analysis Method:   >90.0%(T)

Product Number:   P2143 | Purity / Analysis Method:   >98.0%(HPLC)