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CAS RN: 957-68-6 | Product Number: A1266

7-Aminocephalosporanic Acid


Purity: >97.0%(T)(HPLC)
Synonyms:
  • 7-ACA
Documents:
5G
£16.00
2   ≥40 
25G
£39.00
8   32  

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Product Number A1266
Purity / Analysis Method >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__2N__2O__5S = 272.28 
Physical State (20 deg.C) Solid
CAS RN 957-68-6
PubChem Substance ID 87562732
Merck Index (14) 434
MDL Number

MFCD00005177

Specifications
Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Neutralization titration) min. 97.0 %
Specific rotation [a]20/D +88.0 to +94.0 deg(C=0.5, buffer sol.pH7.0 KH2PO4)
Properties (reference)
Specific Rotation 90° (C=0.5,buffer sol. pH7.0 KH2PO4)
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H317 : May cause an allergic skin reaction.
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P284 : Wear respiratory protection.
P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor.
P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Related Laws:
EC Number 213-485-0
Transport Information:
HS Number 2941100000
Application
7-Aminocephalosporanic Acid (7-ACA): a Starting Compound for Semisynthetic Cephalosporin Antibiotics.

The enzymatic conversion of cephalosporin C gives 7-aminocephalosporanic acid (7-ACA) [A1266], which is used as a starting compound for semisynthetic cephalosporin antibiotics. Modification of 7-ACA at the 3- and 7-positions gives rise to a number of third and fourth semisynthetic cephalosporin antibiotics that are significantly generally more active against Gram-negative bacteria than first and second generation ones. Differences in side chain structure at the 7-position directly affect their antibiotic activity, whereas modifications made at the 3-position influence their metabolism and pharmacokinetic properties of the drugs.

References


PubMed Literature


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