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CAS RN: 125-84-8 | Product Number: A1947

DL-Aminoglutethimide


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 3-(4-Aminophenyl)-3-ethylpiperidine-2,6-dione
Documents:
1G
£15.00
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25G
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Product Number A1947
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__3H__1__6N__2O__2 = 232.28  
Physical State (20 deg.C) Solid
CAS RN 125-84-8
Reaxys Registry Number 210656
PubChem Substance ID 87558926
Merck Index (14) 440
MDL Number

MFCD00010122

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 150.0 to 154.0 °C
Solubility in Acetone very faint turbidity
Properties (reference)
Melting Point 152 °C
Solubility (soluble in) Acetone
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
EC Number 204-756-4
RTECS# MA4026950
Transport Information:
HS Number 2933399990
Application
DL-Aminoglutethimide: A Potent but Nonselective Aromatase Inhibitor

DL-Aminoglutethimide is a first generation, and a potent but nonselective aromatase inhibitor. Aminoglutethimide inhibits the enzymatic side-chain cleavage of cholesterol [C0318] to pregnenolone [P0786], mediated through the binding of aminoglutethimide to cytochrome P 450, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens. Besides, aminoglutethimide-P450 complexes block enzymatic 11- and 18-hydroxylation steps required for the aromatization of androgens to estrogens. Aminoglutethimide is used for the treatment of Cushing’s syndrome, breast and prostate cancer. (The product is for research purpose only.)

References


PubMed Literature


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