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CAS RN: 7177-48-2 | Product Number: A2092

Ampicillin Trihydrate

Purity: >98.0%(T)(HPLC)
  • D-(-)-α-Aminobenzylpenicillin Trihydrate
≥20  ≥20 
1   ≥20 

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This product has not been tested for potency and is guaranteed for chemical purity.

Product Number A2092
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__6H__1__9N__3O__4S·3H__2O = 403.46  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 7177-48-2
Related CAS RN 69-53-4
Reaxys Registry Number 5399534
PubChem Substance ID 87560211
Merck Index (14) 586
MDL Number


Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %(calcd.on anh.substance)
Specific rotation [a]20/D +280.0 to +305.0 deg(C=0.5, H2O)(calcd.on anh.substance)
Water 12.0 to 15.0 %
Properties (reference)
Melting Point 202 °C(dec.)
Specific Rotation 293° (C=0.5,H2O)
Solubility in water Practically insoluble
Degree of solubility in water 10 g/l   21 °C
Solubility (very slightly) Ethanol
Solubility (insoluble in) Benzene,Ether,Chloroform
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H362 : May cause harm to breast-fed children.
Precautionary Statements P263 : Avoid contact during pregnancy and while nursing.
P260 : Do not breathe dust or mist.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
Related Laws:
RTECS# XH8425000
Transport Information:
HS Number 2941100000
Ampicillin: The First of Broad Spectrum Penicillins

Ampicillin, a penicillin-like antibiotic, is enzymatic synthesized from 6-APA [A0800] catalyzed by penicillin acylase. Ampicillin is the first of a number of so-called broad spectrum penicillins. That amino group helps the drug penetrate the outer membrane of Gram-negative bacteria. Thus, ampicillin has activity against not only Gram-positive bacteria such as Staphylococci and Streptococci but also Gram-negative bacteria such as H. influenzae, coliforms and Proteus species. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Its spectrum of activity is enhanced by co-administration of sulbactam [S0868], a drug that inhibits beta lactamase an enzyme produced by bacteria to inactivate ampicillin. Ampicillin is used in molecular biology as a selective reagent most commonly to isolate bacteria coupled to a gene coding for ampicillin resistance, which is one of the most frequently used selection markers for obtaining transgenic cells.


PubMed Literature

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