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CAS RN: 63968-64-9 | Product Number: A2118

Artemisinin


Purity: >97.0%(HPLC)
Synonyms:
  • Arteannuin
  • Qinghaosu
Documents:
1G
£29.00
2   ≥20 
5G
£88.00
3   ≥20 

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Product Number A2118
Purity / Analysis Method >97.0%(HPLC)
Molecular Formula / Molecular Weight C__1__5H__2__2O__5 = 282.34  
Physical State (20 deg.C) Solid
CAS RN 63968-64-9
Reaxys Registry Number 4194670
PubChem Substance ID 87560451
Merck Index (14) 817
MDL Number

MFCD00081057

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Melting point 151.0 to 155.0 °C
Specific rotation [a]20/D +70.0 to +80.0 deg(C=0.5, MeOH)
Properties (reference)
Melting Point 153 °C
Specific Rotation 75° (C=0.5,MeOH)
Solubility (soluble in) Methanol
GHS
Related Laws:
RTECS# KD4170000
Transport Information:
HS Number 2932990090
Application
Artemisinin: An Antimalarial Sesquiterpene Lactone

Artemisinin is a fast-acting and widely used antimalarial agent. Artemisinin was first isolated in 1971 from Chinese medicinal herb Artemisia annua by Tu, a Chinese scientist, who was awarded the Nobel Prize in Physiology or Medicine with Omura and Campbell in 2015. After the activity of artemisinin had been established, several analogs such as such as artemether [A2190], artesunate [A2191] and dihydroartemisinin [D3793] were developed to improve bioavailability and efficacy. Artemisinin and its analogs have high efficacy against Plasmodium falciparum in the blood stages of the disease. The exact mechanism of action is still not clear, while the endoperoxide (O-O) subunit of the trioxane ring is critical for antimalarial activity. Several lines of evidence indicate that the O-O bond is easily broken by Fe2+, generating a number of reactive radicals oxidatively damage parasite. (The product is for research purpose only.)

References


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