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CAS RN: 84692-91-1 | Product Number: A3449

Arglabin


Purity: >98.0%(HPLC)
Synonyms:
  • (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
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5MG
£316.00
1   10  

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Product Number A3449
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__5H__1__8O__3 = 246.31 
Physical State (20 deg.C) Solid
Storage Temperature Frozen (-20°C)
Condition to Avoid Light Sensitive,Heat Sensitive
CAS RN 84692-91-1
Reaxys Registry Number 3549528
PubChem Substance ID 468590304
MDL Number

MFCD11519463

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation +101 to +104 deg (C=0.3, CHCl3)
NMR confirm to structure
Properties (reference)
Melting Point 102 °C
GHS
Related Laws:
Transport Information:
HS Number 2932209090
Application
Arglabin: A Natural NLRP3 Inhibitor

Arglabin, a sesquiterpene γ-lactone, is originally extracted from Artemisia glabella, and also is found in Artemisia myiantha (a species of wormwood) which is a plant commonly used in traditional Chinese medicine.1,2) Arglabin and its derivatives have been reported as NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome inhibitors which show anti-inflammatory antitumor, and antiviral (including anti-SARS-CoV-2) activities.2-5) The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.2) (The product is for research purpose only.)

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