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Published TCIMAIL newest issue No.199
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CAS RN: 188062-50-2 | Product Number: A3532
Abacavir Sulfate
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Purity: >95.0%(T)(HPLC)
Synonyms:
- Abacavir Hemisulfate
- [(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol Hemisulfate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
£88.00
|
Contact Us | 22 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A3532 |
Purity / Analysis Method 
|
>95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__3__6N__1__2O__2·H__2O__4S = 670.75 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Hygroscopic,Heat Sensitive |
| CAS RN | 188062-50-2 |
| Reaxys Registry Number | 10402665 |
| MDL Number | MFCD04112763 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| Specific rotation | -38.0 to -42.0 deg(C=0.5, methanol) |
| Water | max. 1.0 % |
| NMR | confirm to structure |
Properties (reference)
| Solubility in water | Soluble |
| Degree of solubility in water | 77,000 mg/l 25 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 : Wear respiratory protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
Related Laws:
Transport Information:
| HS Number | 2933599590 |
Application
Abacavir Sulfate: A Nucleoside Analog Reverse Transcriptase Inhibitor (RTI)
Abacavir sulfate (1592U89 sulfate), a sulfate salt form of abacavir [A2694], is a nucleoside reverse transcriptase inhibitor (RTI) that inhibits HIV-1 in vitro with a potency similar to that of zidovudine [A2052]. Abacavir is converted by cellular enzymes to the active metabolite, carbovir triphosphate (CBV-TP) which is an analogue of deoxyguanosine-5’-triphosphate (dGTP). CBV-TP is incorporated into the virus DNA strand in place of dGTP, and inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP. (The product is for research purpose only.)
References
- 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity
- Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89
- Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
- Separation and characterization of forced degradation products of abacavir sulphate by LC–MS/MS
- Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography
Product Documents (Note: Some products will not have analytical charts available.)
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