CAS RN: 18531-94-7 | Product Number: B1142
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
|Appearance||White to Light yellow powder to crystal|
|Purity(HPLC)||min. 98.0 area%|
|Optical purity(LC)||min. 98.0 ee%|
|Purity(Neutralization titration)||min. 98.0 %|
|Melting point||207.0 to 212.0 °C|
|Solubility in THF||within almost transparency|
|Melting Point||210 °C|
|Specific Rotation||36° (C=1,THF)|
|Solubility in water||Insoluble|
|Solubility (soluble in)||Ethanol,Tetrahydrofuran|
|Solubility (slightly sol. in)||Toluene|
|Hazard Statements||H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H341 : Suspected of causing genetic defects.
|Precautionary Statements||P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
In a 25 mL round-bottom flask (R)-(+)-BINOL (1.2 eq.) is dried under vacuum for 30 min and dissolved in THF (10 mL). The mixture is cooled to －78 °C, and PhLi (2.4 eq.) is added dropwise under inert atmosphere. Then the mixture is warmed to ambient temperature and stirred for 30 min. The colorless reaction mixture is cooled again to －78 °C, and 4-phenylpyridine N-oxide or pyridine N-oxide (1.0 eq.) is added. The mixture is allowed to reach room temperature, where it is stirred for another 60 min. A yellow mixture is obtained and cooled to －78 °C. To this cooled mixture, R1MgBr (3 eq.) in THF is added dropwise and stirred for 40 min (followed by LC-MS). A fresh NaBH4 (3 eq.) suspension in MeOH (2 mL) is added to the mixture, which thereafter is allowed to reach room temperature. CH2Cl2 (20 mL) and H2O (10 mL) are added to the reaction mixture, and the organic layer is shaken with 10%NaOH aq. (3×10 mL) and then washed with H2O, dried (Na2SO4) and concentrated under reduced pressure. The crude reaction mixture is purified by flash silica column chromatography (AcOEt―Heptane).
- R. Noyori, et al., J. Am. Chem. Soc. 1979, 101, 3129.
- M. Nishizawa, R. Noyori, Tetrahedron Lett. 1980, 21, 2821.
- A. Miyashita, et al., J. Am. Chem. Soc. 1980, 102, 7932.
- S. Sakane, et al., J. Am. Chem. Soc. 1983, 105, 6154.
Safety Data Sheet (SDS)
The requested SDS is not available.
Please Contact Us for more information.
C of A & Other Certificates
The requested Analytical Chart is not available.