CAS RN: 68641-49-6 | Product Number: B1213
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|Purity / Analysis Method||>97.0%(T)|
|Molecular Formula / Molecular Weight||C__6H__8ClN__2O__5P = 254.56|
|Physical State (20 deg.C)||Solid|
|Store Under Inert Gas||Store under inert gas|
|Condition to Avoid||Moisture Sensitive|
|Reaxys Registry Number||3654596|
|PubChem Substance ID||87564149|
|SDBS (AIST Spectral DB)||18273|
|Appearance||White to Almost white powder to crystal|
|Purity(Argentometric Titration)||min. 97.0 %|
|Solubility in N,N-DMF||almost transparency|
|Melting Point||191 °C|
|Solubility (soluble in)||Dimethylformamide|
|Hazard Statements||H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled.
H314 : Causes severe skin burns and eye damage.
H290 : May be corrosive to metals.
|Precautionary Statements||P260 : Do not breathe dust or mist.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
N,N-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic chloride (1.27 g, 5 mmol) is added to a solution of cyanoacetic acid (0.43 g, 5 mmol) and triethylamine (0.7 mL, 5 mmol) in dichloromethane (10 mL). The suspension is stirred for 30 minutes under cooling with an ice bath. Aniline (0.46 mL, 5 mmol) is added and then triethylamine (0.7 mL, 5 mmol) in dichloromethane (2 mL) is added dropwise during 120 minutes at the same temperature. Water (20 mL) and 4 N hydrochloric acid are added to pH 1-1.5. The precipitated amide is filtered off. The organic layer is washed with a solution of sodium hydrogen carbonate and evaporated to yield more 2-cyano-N-phenylacetamide (0.76 g, 95%).
- 1)A new reagent for activating carboxyl groups; preparation and reactions of N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride
- 2)Bis(2-oxo-3-oxazolidinyl)phosphinic chloride as a coupling reagent for N-alkyl amino acids
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