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CAS RN: 68641-49-6 | Product Number: B1213
Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride
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Purity: >97.0%(T)
Synonyms:
- Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic Chloride
- BOP-Cl
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£15.00
|
2 | ≥20 |
|
| 25G |
£56.00
|
1 | ≥20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B1213 |
| Purity / Analysis Method | >97.0%(T) |
| Molecular Formula / Molecular Weight | C__6H__8ClN__2O__5P = 254.56 |
| Physical State (20 deg.C) | Solid |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Moisture Sensitive |
| CAS RN | 68641-49-6 |
| Reaxys Registry Number | 3654596 |
| PubChem Substance ID | 87564149 |
| SDBS (AIST Spectral DB) | 18273 |
| MDL Number | MFCD00010077 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Argentometric Titration) | min. 97.0 % |
| Solubility in N,N-DMF | almost transparency |
Properties (reference)
| Melting Point | 191 °C |
| Solubility (soluble in) | Dimethylformamide |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H314 : Causes severe skin burns and eye damage. H290 : May be corrosive to metals. |
| Precautionary Statements | P260 : Do not breathe dust or mist. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P301 + P330 + P331 : IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. |
Related Laws:
| RTECS# | SZ5871000 |
Transport Information:
| UN Number | UN3261 |
| Class | 8 |
| Packing Group | II |
| HS Number | 2934999090 |
Application
Reagent for Activating Carbonyl Group / Condensation Reagent
Typical Procedure (Entry 1):
N,N-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic chloride (1.27 g, 5 mmol) is added to a solution of cyanoacetic acid (0.43 g, 5 mmol) and triethylamine (0.7 mL, 5 mmol) in dichloromethane (10 mL). The suspension is stirred for 30 minutes under cooling with an ice bath. Aniline (0.46 mL, 5 mmol) is added and then triethylamine (0.7 mL, 5 mmol) in dichloromethane (2 mL) is added dropwise during 120 minutes at the same temperature. Water (20 mL) and 4 N hydrochloric acid are added to pH 1-1.5. The precipitated amide is filtered off. The organic layer is washed with a solution of sodium hydrogen carbonate and evaporated to yield more 2-cyano-N-phenylacetamide (0.76 g, 95%).
N,N-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic chloride (1.27 g, 5 mmol) is added to a solution of cyanoacetic acid (0.43 g, 5 mmol) and triethylamine (0.7 mL, 5 mmol) in dichloromethane (10 mL). The suspension is stirred for 30 minutes under cooling with an ice bath. Aniline (0.46 mL, 5 mmol) is added and then triethylamine (0.7 mL, 5 mmol) in dichloromethane (2 mL) is added dropwise during 120 minutes at the same temperature. Water (20 mL) and 4 N hydrochloric acid are added to pH 1-1.5. The precipitated amide is filtered off. The organic layer is washed with a solution of sodium hydrogen carbonate and evaporated to yield more 2-cyano-N-phenylacetamide (0.76 g, 95%).
References
- 1)A new reagent for activating carboxyl groups; preparation and reactions of N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride
- 2)Bis(2-oxo-3-oxazolidinyl)phosphinic chloride as a coupling reagent for N-alkyl amino acids
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