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CAS RN: 153254-09-2 | Product Number: B3022

2,4-Bis(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)


Purity:
Synonyms:
  • 2,4-Bis(trifluoromethyl)benzeneboronic Acid (contains varying amounts of Anhydride)
Documents:
1G
£38.00
1   5  
5G
£126.00
3   ≥20 

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Product Number B3022
Molecular Formula / Molecular Weight C__8H__5BF__6O__2 = 257.93  
Physical State (20 deg.C) Solid
CAS RN 153254-09-2
Reaxys Registry Number 10175108
PubChem Substance ID 87559527
MDL Number

MFCD01631349

Specifications
Appearance White to Light yellow powder to crystal
Purity(Neutralization titration) 97.0 to 108.0 %
Properties (reference)
Solubility (soluble in) Methanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
Transport Information:
HS Number 2931399090
Application
TCI Practical Example: Condensation Reaction Utilizing the Boronic Acid Catalyst

TCI反応実例:ボロン酸触媒を用いた縮合反応

Used Chemicals

Procedure

To a solution of benzoic acid (122 mg, 1.0 mmol) and benzylamine (107 mg, 1.0 mmol) in fluorobenzene (5 mL, 0.2 mol/L) was added molecular sieves 3A (2 g) at room temperature. After that 2,4-bis(trifluoromethyl)phenylboronic acid (13 mg, 0.05 mmol) was added to the reaction mixture and stirred at reflux temperature for 24 hours. The reaction mixture was filtered on celite pad and washed with EtOAc. The filtrate was washed with 2 mol/L HCl aq. (30 mL), saturated NaHCO3 aq. (30 mL), and brine (30 mL), dried over sodium sulfate and filtered. The solvent was removed under reduced pressure to give N-benzylbenzamide as a white solid (135 mg, 64%).

Experimenter’s Comments

The reaction mixture was monitored by LC.

Analytical Data

N-benzylbenzamide

1H NMR (270 MHz, DMSO-d6); δ 9.05 (brt, 1H, J = 5.4 Hz), 7.90 (dd, 1H, J = 7.3, 1.6 Hz), 7.56-7.44 (m, 3H), 7.36-7.32 (m, 4H), 7.25 (q, 1H, J = 7.3 Hz).

Lead Reference


PubMed Literature


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