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CAS RN: 58-08-2 | Product Number: C2042

Caffeine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 1,3,7-Trimethylxanthine
Documents:
25G
£16.00
4   ≥20 
500G
£51.00
10   ≥20 

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Product Number C2042
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__8H__1__0N__4O__2 = 194.19  
Physical State (20 deg.C) Solid
CAS RN 58-08-2
Reaxys Registry Number 17705
PubChem Substance ID 87558398
Merck Index (14) 1636
Specifications
Appearance White to Almost white powder to crystaline
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Solubility in hot Methanol almost transparency
Properties (reference)
Melting Point 238 °C
Solubility in water Slightly soluble
Degree of solubility in water 21.7 grm/l  
Solubility (very soluble in) Tetrahydrofuran
Solubility (soluble in) Chloroform
Solubility (slightly sol. in) Acetone,Benzene,Alcohol
Solubility (very slightly) Ether
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H332 : Harmful if inhaled.
H360 : May damage fertility or the unborn child.
H412 : Harmful to aquatic life with long lasting effects.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws:
EC Number 200-362-1
RTECS# EV6475000
Transport Information:
UN Number UN1544
Class 6.1
Packing Group III
HS Number 2939300000
Application
Caffeine: A Non-Selective Adenosine Receptor Antagonist, and an Inhibitor Cell Cycle of Progression

Caffeine is widely contained in foods and beverages and is the most widely consumed central-nervous-system stimulant.1) It has been known that adenosine is a modulator that has a pervasive and generally inhibitory effect on neuronal activity. Caffeine, a mimic of adenosine, has the opposite effect of adenosine, and causes most of its biological effects via antagonizing all types of adenosine receptors (ARs), such as A1, A2A, A3, and A2B.2) Besides, it has been reported that caffeine is capable of abrogating cell cycle checkpoints in several different mammalian cell types.3,4) Caffeine has been used to help delineate the role of p53 (cellular tumor antigen p53 gene) in the G2 arrest that occurs in response to DNA damage.3) (The product is for research purpose only.)

References


PubMed Literature


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