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CAS RN: 59865-13-3 | Product Number: C2408
Cyclosporin A
Purity: >97.0%(HPLC)(N)
Synonyms:
- Cyclosporin
Documents:
Size | Unit Price | Belgium | Japan* | Quantity |
---|---|---|---|---|
100MG |
£22.00
|
2 | ≥20 |
|
1G |
£114.00
|
6 | ≥20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Product Number | C2408 |
Purity / Analysis Method | >97.0%(HPLC)(N) |
Molecular Formula / Molecular Weight | C__6__2H__1__1__1N__1__1O__1__2 = 1202.64 |
Physical State (20 deg.C) | Solid |
Storage Temperature | 0-10°C |
Condition to Avoid | Heat Sensitive |
CAS RN | 59865-13-3 |
Reaxys Registry Number | 3647785 |
PubChem Substance ID | 125307331 |
Merck Index (14) | 2752 |
MDL Number | MFCD00274558 |
Specifications
Appearance | White to Almost white powder to crystal |
Purity(HPLC) | min. 97.0 area% |
Purity(with Total Nitrogen) | min. 97.0 % |
Specific rotation [a]20/D | -185 to -193 deg(C=0.5, MeOH) |
Properties (reference)
Melting Point | 151 °C |
Specific Rotation | -193° (C=0.5,MeOH) |
Solubility (very soluble in) | Ether,Acetone,Methanol,Ethanol |
Solubility (soluble in) | Chloroform |
GHS
Pictogram |
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Signal Word | Danger |
Hazard Statements | H302 : Harmful if swallowed. H360 : May damage fertility or the unborn child. H362 : May cause harm to breast-fed children. H350 : May cause cancer. |
Precautionary Statements | P263 : Avoid contact during pregnancy and while nursing. P260 : Do not breathe dust or mist. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. |
Related Laws:
RTECS# | GZ4120000 |
Transport Information:
HS Number | 2941900000 |
Application
Cyclosporin A: A Calcineurin Inhibitor with Immunosuppressive Properties
Cyclosporin A (CsA) is a cyclic polypeptide immunosuppressant, and was initially isolated from the fungus Tolypocladium inflatum Gams in 1970. Cyclosporin A is practically insoluble in water, soluble in diethyl ether, and very soluble in methanol, ethanol and acetonitrile. Cyclosporin A inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that cyclosporin A is inactive by itself and requires binding to an intracellular protein, cyclophiline D (CypD), for activation in cells. A complex of CsA–CypD, calcium, calmodulin, and calcineurin (a calcium and calmodulin dependent protein phosphatase) is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent both T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus (FK506) [M2258] is also inhibits calcineurin and is more potent than cyclosporin A. Cyclosporin A is mainly metabolized by cytochrome P 450 IIIA (CYP3A) subfamilies. (The product is for research purpose only.)
References
- Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
- Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
- The mechanism of action of cyclosporin A and FK506
- Cyclosporin A, FK-506, and rapamycin: Pharmacologic probes of lymphocyte signal transduction
- Mechanisms of action of cyclosporine
- Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state
- Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury
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