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Published TCIMAIL newest issue No.199
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CAS RN: 61422-45-5 | Product Number: C2663
Carmofur
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 5-Fluoro-1-hexylcarbamoyluracil
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
£152.00
|
Contact Us | 1 |
|
|
| 5G |
£689.00
|
Contact Us | 27 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | C2663 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__1H__1__6FN__3O__3 = 257.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 61422-45-5 |
| Reaxys Registry Number | 888898 |
| PubChem Substance ID | 160871373 |
| Merck Index (14) | 1844 |
| MDL Number | MFCD00866284 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 112 °C(dec.) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Acetone, Chloroform |
| Solubility (slightly sol. in) | Ethanol, Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| RTECS# | UV7714000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933599590 |
Application
Carmofur (HCFU): 1-Hexylcarbamoyl Derivative of 5-FU
Carmofur (other name: HCFU) is an ester prodrug and metabolized by the action of CYP450 to form the active metabolite 5-FU [F0151].
References
- Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors
- Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil in a variety of mouse tumors
- Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites
- Studies on the interaction between 1-hexylcarbamoyl-5-fluorouracil and bovine serum albumin
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