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CAS RN: 58-32-2 | Product Number: D2274

Dipyridamole


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
  • 2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol
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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number D2274
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__4H__4__0N__8O__4 = 504.64 
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 58-32-2
Reaxys Registry Number 68373
PubChem Substance ID 87568711
SDBS (AIST Spectral DB) 19363
Merck Index (14) 3346
MDL Number

MFCD00010555

Specifications
Appearance Light yellow to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
NMR confirm to structure
Properties (reference)
Melting Point 168 °C
Solubility (soluble in) Chloroform
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
H370 : Causes damage to organs.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
Related Laws:
EC Number 200-374-7
RTECS# KK7450000
Transport Information:
HS Number 2933998090
Application
Dipyridamole: A Phosphodiesterase (PDE) Inhibitor

Dipyridamole is a phosphodiesterase (PDE) inhibitor.1,2) PDE is a enzyme known to break a phosphodiester bond and degrade cyclic nucleotides. Dipyridamole increases the intracellular levels of cyclic adenosine monophosphate (cAMP) [A2381] and cyclic guanine monophosphate (cGMP) by preventing their conversion to their monophosphates AMP [A0158] and GMP, respectively. Therefore, dipyridamole prevents platelet aggregation by increasing cAMP and cGMP. Furthermore, dipyridamole inhibits the uptake of adenosine into platelets, endothelial cells and erythrocytes. This inhibition results in an increase in local concentrations of adenosine thereby stimulating platelet adenylate cyclase and increasing platelet cAMP levels. In clinical, dipyridamole is used as an antithrombotic agent with antiplatelet activity. Recently, it has been suggested that dipyridamole has beneficial effects for the treatment of COVID-19.3,4) (The product is for research purpose only.)

References


PubMed Literature


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