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CAS RN: 3094-09-5 | Product Number: D3579

5'-Deoxy-5-fluorouridine


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 5'-dFUrd
  • Doxifluridine
  • 1-(5-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
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1G
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5G
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Product Number D3579
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__9H__1__1FN__2O__5 = 246.19 
Physical State (20 deg.C) Solid
CAS RN 3094-09-5
Reaxys Registry Number 890191
PubChem Substance ID 87559877
Merck Index (14) 3437
MDL Number

MFCD00866530

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 189.0 to 193.0 °C
Specific rotation [a]20/D +18.0 to +22.0 deg(C=1, H2O)
Properties (reference)
Melting Point 189 °C
Specific Rotation 20° (C=1,H2O)
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H373 : May cause damage to organs through prolonged or repeated exposure.
H317 : May cause an allergic skin reaction.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P260 : Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P280 : Wear protective gloves.
P314 : Get medical advice/ attention if you feel unwell.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention.
Related Laws:
EC Number 221-440-1
RTECS# YU7526000
Transport Information:
HS Number 2940000080
Application
5'-Deoxy-5-Fluorouridine (Doxifluridine): A Prodrug of Active Antitumor 5-FU

5'-Deoxy-5-fluorouridine (doxifluridine) is a prodrug of active antitumor 5-FU [F0151] and an intermediary metabolite of capecitabine [C2878] and 5'-deoxy-5-fluorocytidine [D4342]. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine and doxifluridine, to form 5-FU. Capecitabine and its intermediary metabolites are not cytotoxic by themselves. The final step (doxifluridine to 5-FU) requires thymidine phosphorylase (dThdPase) that is significantly more active in tumor than normal tissue. This tumor-selective delivery of 5-FU ensured greater efficacy and a more favorable safety profile than with other fluoropyrimidines. (The product is for research purpose only.)

References


PubMed Literature


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