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CAS RN: 863329-66-2 | Product Number: D4823

PSI-6206


Purity: >98.0%(T)(HPLC)
Synonyms:
  • (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
  • RO 2433
Documents:
200MG
£52.00
1   ≥20 
1G
£183.00
2   8  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number D4823
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__3FN__2O__5 = 260.22  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 863329-66-2
Reaxys Registry Number 10267735
PubChem Substance ID 253661201
MDL Number

MFCD27918669

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Specific rotation [a]20/D +87.0 to +92.0 deg(C=1,MeOH)
Properties (reference)
Melting Point 234 °C(dec.)
Specific Rotation 89° (C=1,MeOH)
GHS
Related Laws:
Transport Information:
HS Number 2934999090
Application
A Selective Nucleoside Polymerase Inhibitor of Hepatitis C Virus (HCV)

(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine (other name: PSI-6206 or β-D-2'-deoxy-2'-fluoro-2'-C-methyluridine) is a selective nucleoside polymerase inhibitor of hepatitis C virus (HCV) replication that targets the NS5B polymerase. Recently, to improve pharmacokinetic properties for clinical use, some prodrugs of the 5'-phosphate derivative of PSI-6206 have been developed. In addition, PSI-6206 is an active metabolite of PSI-6130 (β-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine).

References


PubMed Literature


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