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CAS RN: 140681-55-6 | Product Number: F0358

N-Fluoro-N'-(chloromethyl)triethylenediamine Bis(tetrafluoroborate)

Purity: >95.0%(T)
  • 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate)
  • F-TEDA-BF4
2   16  
4   ≥20 
3   ≥20 

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Product Number F0358
Purity / Analysis Method >95.0%(T)
Molecular Formula / Molecular Weight C__7H__1__4B__2ClF__9N__2 = 354.26  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Moisture Sensitive
CAS RN 140681-55-6
Reaxys Registry Number 5368649
PubChem Substance ID 87570129
Merck Index (14) 8425
MDL Number


Appearance White to Light yellow powder to crystal
Purity(Iodometric Titration) min. 95.0 %
Properties (reference)
Melting Point 175 °C
Solubility in water Soluble
Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H302 : Harmful if swallowed.
H318 : Causes serious eye damage.
H317 : May cause an allergic skin reaction.
H412 : Harmful to aquatic life with long lasting effects.
may catch fire.
Precautionary Statements P261 : Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P235 : Keep cool.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
P407 : Maintain air gap between stacks or pallets.
Related Laws:
Transport Information:
UN Number UN3088
Class 4.2
Packing Group II
HS Number 2933599565
Metal-Free Fluorination of C(sp3)-H Bonds using a Catalytic N-Oxyl Radical


Typical Procedure: To a solution of 4-phenylbutyl benzoate (55.6 mg, 0.219 mmol) and NDHPI (1.36 mg, 0.00547 mmol) in MeCN (2.2 mL) is added F-TEDA-BF4 (155 mg, 0.438 mmol) at room temperature. The mixture is degassed by freeze-thaw for 3 times under Ar atmosphere, and stirred at 50 °C for 5 h. The reaction mixture is then neutralized with saturated aqueous NaHCO3, and extracted with EtOAc (3 mL×3). The combined organic layers are dried over Na2SO4, and concentrated. The residue is purified with flash column chromatography (silica gel, hexane : Et2O=30 : 1) to provide 4-benzoyloxy-1-phenylbutyl fluoride (43.1 mg, Y. 72%).


Regioselective Fluorohydroxylation Reaction of Arylallenes


Regiospecific fluorination of functionalized phenols

Typical procedue: To 4-(biphenyl)tributylstananne (44.3 mg) in acetone (2.0 mL) at 23°C is added silver triflate (51.4 mg) and N-fluoro-N'-(chloromethyl)triethylenediamine bis(tetrafluoroborate) (F-TEDA-BF4) (42.5 mg). The reaction mixture is stirred for 20 min at 23°C and then concentrated in vacuo. The residue is purified by preparative TLC eluting with hexane to give 12.0 mg of the fluorinated compound as colorless solid (70% yield).


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