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CAS RN: 104227-87-4 | Product Number: F0842

Famciclovir


Purity: >98.0%(T)(HPLC)
Synonyms:
  • 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol Diacetate
Documents:
500MG
£35.00
3   17  
5G
£186.00
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Note:

This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.

Product Number F0842
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__4H__1__9N__5O__4 = 321.34  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 104227-87-4
Reaxys Registry Number 4208403
PubChem Substance ID 160871205
MDL Number

MFCD00866964

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Melting point 103.0 to 107.0 °C
Properties (reference)
Melting Point 105 °C
Maximum Absorption Wavelength 310(EtOH) nm
Solubility in water Slightly soluble
Solubility (soluble in) Methanol,Ethanol
GHS
Related Laws:
RTECS# TY3164000
Transport Information:
HS Number 2933599590
Application
Studies on the Antiviral Activities of Famciclovir

Famciclovir is a prodrug of penciclovir [P2164] which is an anti-herpesvirus agent. It has demonstrated inhibitory activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), and varicella zoster virus (VZV). The viral thymidine kinase (TK) phosphorylates penciclovir to a monophosphate form. Subsequently, the monophosphate s converted to penciclovir triphosphate by cellular kinases. The triphosphate inhibits virus DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, famciclovir interfere with herpes viral DNA synthesis and replication. In contrast, human cellular TK have very little ability to add the initial phosphate group to famciclovir (penciclovir), which has extremely low toxicity for human cell. (The product is for research purpose only.)

References


PubMed Literature


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