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CAS RN: 1953-04-4 | Product Number: G0293

Galantamine Hydrobromide


Purity: >98.0%(T)(HPLC)
Synonyms:
Documents:
100MG
£49.00
2   ≥20 
1G
£300.00
2   ≥20 

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Product Number G0293
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__7H__2__1NO__3·HBr = 368.27  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Hygroscopic,Heat Sensitive
CAS RN 1953-04-4
Related CAS RN 357-70-0
Reaxys Registry Number 3787265
PubChem Substance ID 87558740
Merck Index (14) 4340
Specifications
Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Nonaqueous Titration) min. 98.0 %
Specific rotation [a]20/D -92.0 to -98.0 deg(C=1.4, H2O)
Properties (reference)
Melting Point 256 °C
Specific Rotation -95° (C=1.4,H2O)
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H300 : Fatal if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
EC Number 217-780-5
RTECS# DF8045500
Transport Information:
UN Number UN2811
Class 6.1
Packing Group II
HS Number 2939790090
Application
Galantamine Hydrobromide: A Unique Dual Mode Agent, an Inhibitor of Acetylcholinesterase and an Allosteric Modulator of Nicotinic Acetylcholine Receptors

Galantamine, a tertiary alkaloid found in the bulbs of Galanthus woronowi. Galantamine increases the concentration of acetylcholine (ACh) in brain tissue through competitive and reversible inhibition of its hydrolysis by acetylcholinesterase (AChE). Besides, galantamine stimulates nicotinic acetylcholine receptors (nAChR) as an allosteric potentiating ligand (APL) to enhance brain cholinergic function. Therefore, galantamine has shown potential for the treatment of Alzheimer's disease. Galantamine is metabolized in the liver via cytochrome P450 enzymes CYP2D6 and CYP3A4. (The product is for research purpose only.)

References


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