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CAS RN: 25812-30-0 | Product Number: G0368

Gemfibrozil


Purity: >98.0%(GC)(T)
Synonyms:
  • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic Acid
  • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeric Acid
Documents:
5G
£42.00
3   ≥20 
25G
£148.00
2   9  

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Product Number G0368
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__1__5H__2__2O__3 = 250.34  
Physical State (20 deg.C) Solid
CAS RN 25812-30-0
Reaxys Registry Number 1881200
PubChem Substance ID 125307848
SDBS (AIST Spectral DB) 52970
Merck Index (14) 4388
MDL Number

MFCD00079335

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 59.0 to 63.0 °C
Properties (reference)
Melting Point 61 °C
Boiling Point 159 °C/0.02 mmHg
Solubility (soluble in) Methanol
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
EC Number 247-280-2
RTECS# YV7120000
Transport Information:
HS Number 2918999090
Application
Gemfibrozil: An Antilipemic Fibrate

The fibrates, including gemfibrozil, are lower elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fibrates increase the high density lipoprotein (HDL) cholesterol fraction. The precise mechanisms of action remain unknown, but it has been reported that the major modes of action of the fibrates as follows: VLDL catabolism by increased lipoprotein and hepatic triglyceride lipase activities; suppression of triglyceride biosynthesis by acetyl-CoA carboxylase enzyme inhibition and attenuation of cholesterol biosynthesis by inhibition of the rate-limiting HMG-CoA reductase. In 2000s, it has been reported that concomitant use of gemfibrozil with statins (in particular cerivastatin) increases the risk of rhabdomyolysis which is a serious syndrome due to a muscle injury. (The product is for research purpose only.)

References


PubMed Literature


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