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CAS RN: 21187-98-4 | Product Number: G0381

Gliclazide


Purity: >98.5%(T)(HPLC)
Synonyms:
  • 1-[3-Azabicyclo[3.3.0]oct-3-yl]-3-p-toluenesulfonylurea
Documents:
5G
£52.00
7   ≥20 

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Product Number G0381
Purity / Analysis Method >98.5%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__5H__2__1N__3O__3S = 323.41  
Physical State (20 deg.C) Solid
CAS RN 21187-98-4
Reaxys Registry Number 1657836
PubChem Substance ID 135726993
Merck Index (14) 4439
MDL Number

MFCD00409893

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.5 area%
Purity(Neutralization titration) min. 98.5 %
Melting point 165.0 to 169.0 °C
Properties (reference)
Melting Point 167 °C
Solubility in water Insoluble
Solubility (soluble in) Dimethylformamide
Solubility (slightly sol. in) Methanol,Ethanol
GHS
Related Laws:
EC Number 244-260-5
RTECS# YT4500000
Transport Information:
HS Number 2933998090
Application
Gliclazide: A Sulfonylurea ATP-Dependent K+ Channel Antagonist

Gliclazide belongs to sulfonylurea antidiabetics which increase the release of insulin from pancreatic B-cells. Sulfonylurea antidiabetics inhibit ATP-gated K+ channels and thereby cause depolarization of the B-cell membrane. The depolarization leads to activation of voltage-dependent Ca channels and Ca2+ influx into the B-cell, and eventually increases insulin release. Gliclazide also has hemovascular properties, such as the anti-oxidant, platelet inhibiting and fibrinolytic actions. In addition, gliclazide is characterized by poor solubility in water. Therefore, it has been studied to improve the solubility and bioavailability of drug. (The product is for research purpose only.)

References


Application
Study of Sulfonylureas Receptors

References

  • The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated potassium channel in insulin-secreting cells
    • H. Schmid-Antomarchi, L. De Weille, M. Fosset, M. Lazdunski, J. Biol. Chem. 1987, 262, 15840.
  • Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent potassium channels
    • M. Fosset, J. R. De Weille, R. D. Green, H. Schmid-Antomarchi, M. Lazdunski, J. Biol. Chem. 1988, 263, 7933.


PubMed Literature


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