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CAS RN: 7803-57-8 | Product Number: H0172

Hydrazine Monohydrate


Purity: >98.0%(T)
Synonyms:
Documents:
25ML
£17.00
38   ≥100 
500ML
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18   ≥100 

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Product Number H0172
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight H__4N__2·H__2O = 50.07 
Physical State (20 deg.C) Liquid
CAS RN 7803-57-8
Related CAS RN 10217-52-4
Reaxys Registry Number 878137
PubChem Substance ID 87570605
Merck Index (14) 4771
MDL Number

MFCD00149931

Specifications
Appearance Colorless clear liquid
Purity( Potassium iodate Method) 98.0 to 102.0 %
Solubility in Water transparency
Chloride max. 0.001 %
Sulfate max. 0.005 %
Properties (reference)
Melting Point -52 °C
Boiling Point 119 °C
Flash point 75 °C
Specific Gravity (20/20) 1.03
Refractive Index 1.43
Solubility in water Completely miscible
Solubility (miscible with) Alcohol
Solubility (insoluble in) Ether, Chloroform
GHS
Pictogram Pictogram Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H314 : Causes severe skin burns and eye damage.
H370 : Causes damage to organs.
H372 : Causes damage to organs through prolonged or repeated exposure.
H317 : May cause an allergic skin reaction.
H341 : Suspected of causing genetic defects.
H350 : May cause cancer.
H410 : Very toxic to aquatic life with long lasting effects.
Precautionary Statements P273 : Avoid release to the environment.
P260 : Do not breathe mist or vapours.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.
P391 : Collect spillage.
P308 + P311 : IF exposed or concerned: Call a POISON CENTER/doctor.
P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor.
P305 + P351 + P338 + P310 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor.
Related Laws:
RTECS# MV8050000
Transport Information:
UN Number UN2030
Class 8 / 6.1
Packing Group II
HS Number 2825100090
Application
TCI Practical Example: Electroreduction Using Hydrazine Monohydrate

TCI Practical Example: Electroreduction Using Hydrazine Monohydrate

Used Chemicals

Procedure

Trifluoroacetic acid (0.355 mL, 4.64 mmol, 11.6 eq.) was added to a solution of 1-Phenylpropargyl alcohol (52.9 mg, 0.40 mmol) and hydrazine monohydrate (500 mg, 10.0 mmol, 25 eq.) in methanol (5 mL) at room temperature. An RVC electrode was immersed in the solution and constant current electrolysis was performed at a current of 40 mA until an electrical flow of 45 F/mol was completed. Water (20 mL) was added to the reaction mixture and the aqueous layer was extracted with diethyl ether (20 mL, twice). The combined organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure to give 1-phenyl-1-propanol as a colorless liquid (57.2 mg, >99% yield).

Experimenter’s Comments

The reaction mixture was monitored by UPLC.
The experiment was conducted in a fume hood because gas is produced during the reaction.
The reaction was carried out for about 8 hours.
IKA ElectraSyn 2.0 was used as an electrolytic apparatus in this experiment.

Analytical Data

1-phenyl-1-propanol

1H NMR (400 MHz, CDCl3); δ 7.39–7.26 (m, 5H), 4.59 (t, J = 6.4 Hz, 1H), 2.07 (br s, 1H), 1.88–1.70 (m, 2H), 0.92 (t, J = 7.2 Hz, 3H).

Lead Reference


Application
TCI Practical Example: Pyrazole Ring Construction Reaction Using Hydrazine Monohydrate

TCI Practical Example: Pyrazole Ring Construction Reaction Using Hydrazine Monohydrate

Used Chemicals

Procedure

Hydrazine monohydrate (275 mg, 5.5 mmol, 1.1 eq.) was added to 1,3-diphenyl-1,3-propanedione (1.12 g, 5.0 mmol) in EtOH (20 mL) at room temperature. The mixture was refluxed for 2 hours.Then water (80 mL) was added to the reaction mixture and precipitate was filtered to give 3,5-diphenyl-1H-pyrazole as a white solid (1.05 g, 95% yield).

Experimenter’s Comments

The reaction mixture was monitored by UPLC.

Analytical Data

3,5-Diphenyl-1H-pyrazole

1H NMR (400 MHz, DMSO-d6); δ 7.83-7.75 (m, 4H), 7.43-7.38 (m, 4H), 7.34-7.25 (m, 2H), 7.14 (s, 1H).

Lead Reference


Application
TCI Practical Example: Pyrazole Ring Construction Reaction Using Hydrazine

TCI Practical Example: Pyrazole Ring Construction Reaction Using Hydrazine

Used Chemicals

Procedure

Hydrazine monohydrate (0.267 mL, 5.5 mmol, 1.1 eq.) was added to a solution of 4-phenyl-3-butyn-2-one (0.707 mL, 5.0 mmol) in EtOH (20 mL) at room temperature and the mixture was refluxed for 4 hours. Then the solvent was removed under reduced pressure and the residue was purified by column chromatography (on silica gel, ethyl acetate:hexane = 0:1 - 1:1) to give 5-methyl-3-phenyl-1H-pyrazole as a pale yellow solid (684 mg, 86% yield).

Experimenter’s Comments

The reaction mixture was monitored by UPLC.

Analytical Data

5-Methyl-3-phenyl-1H-pyrazole

1H NMR (400 MHz, CDCl3); δ 7.71 (d, J = 8.0 Hz, 2H), 7.37 (t, J = 7.2 Hz, 2H), 7.32-7.28 (m, 1H), 6.35 (s, 1H), 2.30 (s, 3H).

Lead Reference


PubMed Literature


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