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CAS RN: 15687-27-1 | Product Number: I0415

Ibuprofen


Purity: >98.0%(GC)(T)
Synonyms:
  • 2-(4-Isobutylphenyl)propionic Acid
  • 4-Isobutyl-α-methylphenylacetic Acid
Documents:
25G
£56.00
4   ≥40 
100G
£143.00
1   19  
500G
£345.00
1   16  

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Product Number I0415
Purity / Analysis Method >98.0%(GC)(T)
Molecular Formula / Molecular Weight C__1__3H__1__8O__2 = 206.29 
Physical State (20 deg.C) Solid
CAS RN 15687-27-1
Reaxys Registry Number 2049713
PubChem Substance ID 87571768
SDBS (AIST Spectral DB) 10570
Merck Index (14) 4881
MDL Number

MFCD00010393

Specifications
Appearance White to Almost white powder to crystal
Purity(GC) min. 98.0 %
Purity(Neutralization titration) min. 98.0 %
Melting point 75.0 to 78.0 °C
Solubility in Methanol almost transparency
Properties (reference)
Melting Point 76 °C
Boiling Point 157 °C/4 mmHg
Solubility in water Insoluble
Degree of solubility in water 21 mg/l   25 °C
GHS
Pictogram Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
Related Laws:
EC Number 239-784-6
RTECS# MU6640000
Transport Information:
HS Number 2916399070
Application
Ibuprofen: A Non-Selective Non-Steroidal Anti-Inflammatory Drug (NSAID)

Ibuprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which possesses analgesic and antipyretic activities. Ibuprofen is a racemic compound and the active enantiomer is (S)-(+)-ibuprofen [I0549] which works by inhibiting both the COX-1 and COX-2 enzymes and prostaglandin synthesis. NSAIDs also include ketoprofen [K0038], loxoprofen [L0244] and naproxen [M1021] among others. Resently, some studies have suggested that NSAIDs may reduce the risk of certain types of cancer and Alzheimer's disease. (The product is for research purpose only.)

References


Application
Binding of Ibuprofen to Human Serum Albumin

Ibuprofen is known to have affinity for Human Serum Albumin (HSA) and to bind (interact) to drug binding site II on HSA. Those were confirmed using our ibuprofen with Surface Plasmon Resonance (SPR) and a method using fluorescent probes. 【SPR】Dose responses of ibuprofen to HSA were confirmed by SPR. Biacore, as a SPR biosensor, was used for the assay, according to the user’s guide of the instrument.

<Assay condition> Sensor Chip: Series S Sensor Chip CM5, Immobilization: HAS (Amine Coupling method), Buffer : 5%DMSO in PBS. <Result> “Square wave” sensorgrams were exhibited at each concentration, and concentration dependent binding of ibuprofen to HSA was confirmed. 【Method using fluorescent probes】The drug biding site of ibuprofen was confirmed using fluorescent probes which bind to drug binding site on HSA. Dansylamide (DNSA) [D5405] was used as fluorescent probe for site I, and dansylglycine (DNSG) [D5406], BD140 [D4898] were used as fluorescent probes for site II, and then bindings to site I and site II were confirmed.

<Assay condition> Buffer: 1 % DMSO in phosphate buffer (pH 7.2 - 7.5); HSA: 5 µM (DNSA), 20 µM (DNSG, BD140) (50 µL/well) (Fatty acid free HSA is recommended.); Ibuprofen: each concentration (50 µL/well); DNSA: 80 µM, DNSG: 20 µM, BD140: 20 µM (50 µL/well); Incubation: 20-25 °C for 30 min; Measurement: plate-reader with excitation = 365 nm and emission = 480 nm (DNSA, DNSG), with excitation = 365 nm and emission = 585 nm (BD140). <Result> As shown in upper diagram, inhibition against binding of dansylglycine and BD140 which are fluorescent probes for site II by ibuprofen was confirmed. And also, little or extremely weak inhibition against binding of dansylamide which is fluorescent probe for site I was confirmed. In these ways, our ibuprofen can be used for study of interaction with HSA. Also, DNSA [D5405], DNSG [D5406] and BD140 [D4898] can be used for study of drug binding site on HSA.

References


PubMed Literature


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