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Published TCIMAIL newest issue No.199
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CAS RN: 152459-95-5 | Product Number: I0906
Imatinib
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
£39.00
|
2 | ≥40 |
|
|
| 1G |
£248.00
|
1 | 14 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | I0906 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__3__1N__7O = 493.62 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 152459-95-5 |
| Related CAS RN
|
220127-57-1 |
| Reaxys Registry Number | 9300263 |
| PubChem Substance ID | 253661909 |
| Merck Index (14) | 4902 |
| MDL Number | MFCD05662257 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 97.0 % |
| Melting point | 207.0 to 211.0 °C |
Properties (reference)
| Melting Point | 209 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P337 + P313 : If eye irritation persists: Get medical advice/ attention. |
Related Laws:
| RTECS# | CV5585673 |
Transport Information:
| HS Number | 2933599590 |
Application
Imatinib: A Tyrosine Kinase Inhibitor and a Molecular-Targeted Agent
Imatinib is a synthetic tyrosine (Tyr) kinase inhibitor and a molecular-targeted agent that specifically target several protein tyrosine kinases, such as stem-cell factor receptor (c-KIT), platelet-derived growth factor receptor (PDGF-R), and notably Bcr-Abl. Imatinib mesylate [I0936] is used in the treatment of chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies. (The product is for research purpose only.)
References
- Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
- Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug (a review)
- Mechanisms and implications of imatinib resistance mutations in BCR-ABL (a review)
- The development of imatinib as a therapeutic agent for chronic myeloid leukemia
- Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukemia
PubMed Literature
Documents
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
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