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CAS RN: 469-59-0 | Product Number: J0009

Jervine


Purity: >97.0%(HPLC)
Synonyms:
  • (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one
Documents:
10MG
£133.00
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Product Number J0009
Purity / Analysis Method >97.0%(HPLC)
Molecular Formula / Molecular Weight C__2__7H__3__9NO__3 = 425.61  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 469-59-0
Reaxys Registry Number 59109
PubChem Substance ID 253659677
Merck Index (14) 5264
MDL Number

MFCD01684066

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Melting point 243.0 to 247.0 °C
Properties (reference)
Melting Point 246 °C
Maximum Absorption Wavelength 250 nm
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H360 : May damage fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P201 : Obtain special instructions before use.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 207-417-9
RTECS# WG9700000
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2939790090
Application
Sonic Hedgehog Inhibitor
References

1)Hedgehog: Functions and mechanisms

M. Varjosalo, J. Taipale, Genes Dev. 2008, 22, 2454.

2)Mutations affecting segment number and polarity in Drosophila

C. Nüsslein-Volhard, E. Wieschaus, Nature 1980, 287, 795.

3)Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Y. Echelard, D. J. Epstein, B. St-Jacques, L. Shen, J. Mohler, J. A. McMahon, A. P. McMahon, Cell. 1993, 75, 1417.

4)Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

K. A. D’Amour, A. G. Bang, S. Eliazer, O. G. Kelly, A. D. Agulnick, N. G. Smart, M. A. Moorman, E. Kroon, M. K. Carpenter, E. E. Baetge, Nat. Biotechnol. 2006, 24, 1392.

5)Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1

J.-H. Moon, J. S. Heo, J. S. Kim, E. K. Jun, J. H. Lee, A. Kim, J. Kim, K. Y. Whang, Y.-K. Kang, S. Yeo, H.-J. Lim, D. W. Han, D.-W. Kim, S. Oh, B. S. Yoon, H. R. Schöler, S. You, Cell Res. 2011, 21, 1305.

6)Teratogen-mediated inhibition of target tissue response to Shh signaling

M. K. Cooper, J. A. Porter, K. E. Young, P. A. Beachy, Science 1998, 280, 1603.


PubMed Literature


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