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CAS RN: 7179-49-9 | Product Number: L0166

Lincomycin Hydrochloride Monohydrate


Purity: >98.0%(T)
Synonyms:
  • Lincocin Hydrochloride Monohydrate
Documents:
5G
£73.00
2   ≥20 
25G
£221.00
3   ≥20 

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Product Number L0166
Purity / Analysis Method >98.0%(T)
Molecular Formula / Molecular Weight C__1__8H__3__4N__2O__6S·HCl·H__2O = 461.02  
Physical State (20 deg.C) Solid
CAS RN 7179-49-9
Related CAS RN 859-18-7&154-21-2
Reaxys Registry Number 3580436
PubChem Substance ID 87572117
Merck Index (14) 5500
MDL Number

MFCD00167245

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 97.0 area%
Purity(Nonaqueous Titration) min. 98.0 %(calcd.on anh.substance)
Melting point 151.0 to 157.0 °C
Specific rotation [a]20/D +134 to +139 deg(C=1, H2O)
Solubility in Water almost transparency
Water 3.7 to 4.5 %
Properties (reference)
Melting Point 154 °C
Specific Rotation 137° (C=1,H2O)
GHS
Related Laws:
RTECS# RH6315500
Transport Information:
HS Number 2941100000
Application
Lincomycin Hydrochloride: A Lincosamide Antibiotic with Activity against Anaerobic Bacteria

Lincomycin hydrochloride is a lincosamide antibiotic isolated from the actinomyces Streptomyces lincolnensis. A congener compound, clindamycin [C2256], is derived from lincomycin to replace the 7-hydroxy group with a chlorine atom with inversion of chirality. Lincomycin has broad activity against anaerobic Gram-positive bacteria and anaerobic Gram-negative bacteria with a few exceptions, but less activity against most aerobic Gram-negative bacteria. Lincomycin interacts with the 50s subunit of bacterial ribosomes, and then it inhibits bacterial growth by inhibiting protein synthesis. Bacterial resistance to clindamycin and lincomycin may be caused by methylation of bacterial 23S ribosomal RNA.

References


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