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CAS RN: 75330-75-5 | Product Number: L0214

Lovastatin


Purity: >98.0%(HPLC)
Synonyms:
  • Mevinolin
  • 6α-Methylcompactin
  • Monacolin K
Documents:
5G
£52.00
4   ≥40 
25G
£178.00
1   1  

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Product Number L0214
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__2__4H__3__6O__5 = 404.55 
Physical State (20 deg.C) Solid
Condition to Avoid Light Sensitive
CAS RN 75330-75-5
Reaxys Registry Number 4720754
PubChem Substance ID 87560159
Merck Index (14) 5586
MDL Number

MFCD00072164

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 98.0 area%
Specific rotation [a]20/D +320 to +340 deg(C=0.5, CH3CN)
Properties (reference)
Melting Point 179 °C
Specific Rotation 320° (C=0.5,CH3CN)
Solubility in water Insoluble
Degree of solubility in water 0.4 mg/l   25 °C
Solubility (soluble in) Methanol,Ethanol
GHS
Hazard Statements H413 : May cause long lasting harmful effects to aquatic life.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P273 : Avoid release to the environment.
Related Laws:
RTECS# EK7907000
Transport Information:
HS Number 2932990090
Application
Lovastatin: A Potent HMG-CoA Reductase Inhibitor

Lovastatin is a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. It was first isolated from in a fermentation broth of Aspergillus terreus in 1978, and taken into clinical development as potential agents for lowering LDL cholesterol. Lovastatin is an inactive lactone which is readily hydrolyzed in vivo to the corresponding active beta-hydroxy acid. The active acid inhibits the action of enzyme HMG-CoA reductase that catalyzes the rate-limiting step in cholesterol biosynthesis, resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. (The product is for research purpose only.)

References


Application
HMG-CoA Reductase Inhibitors (Statins)

Lovastatin is a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. It was first isolated from in a fermentation broth of Aspergillus terreus in 1978, and taken into clinical development as potential agents for lowering LDL cholesterol. Lovastatin is an inactive lactone which is readily hydrolyzed in vivo to the corresponding active beta-hydroxy acid. The active acid inhibits the action of enzyme HMG-CoA reductase that catalyzes the rate-limiting step in cholesterol biosynthesis, resulting in the reduction of low-density-lipoprotein (LDL) and total cholesterol levels. (The product is for research purpose only.)

References


PubMed Literature


Documents (Note: Some products will not have analytical charts available.)
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