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CAS RN: 15297-92-4 | Product Number: L0422

LDN-22684


Purity: >98.0%(HPLC)
Synonyms:
  • Dehydro-α-lapachone
  • 2,2-Dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione
  • 2,2-Dimethyl-2H-benzo[g]chromene-5,10-dione
Documents:
100MG
£114.00
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Product Number L0422
Purity / Analysis Method >98.0%(HPLC)
Molecular Formula / Molecular Weight C__1__5H__1__2O__3 = 240.26 
Physical State (20 deg.C) Solid
Storage Temperature Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN 15297-92-4
Reaxys Registry Number 181737
MDL Number

MFCD00022286

Specifications
Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 98.0 area%
Melting point 142.0 to 146.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 145 °C
GHS
Related Laws:
Transport Information:
HS Number 2932990090
Application
LDN-22684: A LRRK2 Inhibitor as a Useful Tool for the Study of Parkinson's disease

The leucine-rich repeat kinase 2 (LRRK2) is a large protein (2527 amino acids) with serine-threonine (Ser/Thr) protein kinase activity and autophosphorylation activity. It is highly expressed in many mammal tissues. Genetic mutations in the G2019S encoding portion of LRRK2 (LRRK2-G2019S) have been detected frequently in Parkinson's (PD) patients.1-3) As a result, LRRK2-G2019S is a promising therapeutic target for the treatment of PD. There are reports, that LDN-22684 inhibited LRRK2-G2019S and wild-type LRRK2 in the low micromole range.1,3) Therefore it is a useful tool for the study of PD. (The product is for research purpose only.)

References


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