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CAS RN: 90-33-5 | Product Number: M0453
4-Methylumbelliferone
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Purity: >98.0%(T)
Synonyms:
- 7-Hydroxy-4-methylcoumarin
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
£22.00
|
1 | ≥40 |
|
| 100G |
£73.00
|
2 | 36 |
|
| 500G |
£367.00
|
1 | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 188.0 to 192.0 °C |
Properties (reference)
| Melting Point | 188 °C |
| Solubility in water | Practically insoluble |
| Solubility (soluble in) | Ethanol |
| Solubility (slightly sol. in) | Ether,Chloroform |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 201-986-7 |
| RTECS# | GN7000000 |
Transport Information:
| HS Number | 2932209090 |
Application
4-Methylumbelliferone: A Hyaluronan Synthesis Inhibitor with Anticancer Properties
Specific inhibitors of hyaluronan biosynthesis can be valuable agents to prevent cancer invasion and metastasis. Recently, 4-methylumbelliferone (MU) has been reported as a hyaluronan synthesis inhibitor with anticancer properties.
References
- A Novel Mechanism for the Inhibition of Hyaluronan Biosynthesis by 4-Methylumbelliferone
- A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells
- 4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in humanpancreatic cancer cells
- Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
- Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo
- Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice
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