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CAS RN: 89-25-8 | Product Number: M0687

3-Methyl-1-phenyl-5-pyrazolone


Purity: >98.0%(T)(HPLC)
Synonyms:
  • Monopyrazolone
  • Edaravone
  • MCI-186
Documents:
25G
£14.00
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500G
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Product Number M0687
Purity / Analysis Method >98.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__1__0H__1__0N__2O = 174.20  
Physical State (20 deg.C) Solid
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive
CAS RN 89-25-8
Reaxys Registry Number 609575
PubChem Substance ID 87572698
SDBS (AIST Spectral DB) 2704
Merck Index (14) 6713
MDL Number

MFCD00003138

Specifications
Appearance White to Orange to Green powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Neutralization titration) min. 98.0 %
Melting point 128.0 to 131.0 °C
Solubility in N,N-DMF almost transparency
Suitability for cyan-analysis to pass test
Properties (reference)
Melting Point 129 °C
Boiling Point 287 °C/265 mmHg
Solubility in water Insoluble
Solubility (slightly sol. in) Chloroform,Dimethylformamide,Alcohol,Benzene
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H302 : Harmful if swallowed.
H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth.
Related Laws:
EC Number 201-891-0
RTECS# UQ9625000
Transport Information:
HS Number 2933199090
Application
Edaravone: A Strong Free Radical Scavenger and a Powerful Antioxidant

Edaravone (MCI-186) is a strong free radical scavenger and a powerful antioxidant. There have been many reports describing that free radicals such as hydroxyl radical (·OH) play a major causative role in the development of cerebral vascular disorder resulting from ischaemia. During ischaemia or ischemic reperfusion, the hyperactivity of a metabolic system of arachidonic acid increases the production of free radicals. These free radicals peroxidize unsaturated fatty acid of cell membrane lipids leads to cell membrane injury. Besides, oxidative stress is believed to contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). Edaravone inhibits lipid peroxidation, and thereby prevents oxidative damage to brain cells or neurons. Consequently, edaravone improves of neurological symptoms, and inhibits the progression of ALS. (The product is for research purpose only.)

References


PubMed Literature


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