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CAS RN: 443-48-1 | Product Number: M0924

2-Methyl-5-nitroimidazole-1-ethanol


Purity: >99.0%(GC)(T)
Synonyms:
  • Metronidazole
Documents:
25G
£19.00
4   ≥20 
500G
£206.00
3   18  

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Product Number M0924
Purity / Analysis Method >99.0%(GC)(T)
Molecular Formula / Molecular Weight C__6H__9N__3O__3 = 171.16  
Physical State (20 deg.C) Solid
CAS RN 443-48-1
Reaxys Registry Number 611683
PubChem Substance ID 87572910
SDBS (AIST Spectral DB) 18702
Merck Index (14) 6157
MDL Number

MFCD00009750

Specifications
Appearance White to Orange to Green powder to crystal
Purity(GC) min. 99.0 %
Purity(Nonaqueous Titration) min. 99.0 %
Melting point 159.0 to 163.0 °C
Solubility in hot Methanol almost transparency
Properties (reference)
Melting Point 161 °C
Solubility in water Slightly soluble
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H351 : Suspected of causing cancer.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
EC Number 207-136-1
RTECS# NI5600000
Transport Information:
HS Number 2933299090
Application
Metronidazole: A Nitroimidazole Antibiotic against Protozoans and Anaerobic Bacteria

2-Methyl-5-nitroimidazole-1-ethanol (metronidazole) is a synthetic nitroimidazole antibiotic such as azomycin [N0891] and dimetridazole [D1564]. Metronidazole has a limited spectrum of activity that encompasses various protozoans and most Gram-negative and Gram-positive anaerobic bacteria. Metronidazole is bactericidal through toxic metabolites (hydroxyl radicals) which cause bacterial DNA strand breakage. Metronidazole is active against Helicobacter pylori, however resistance to metronidazole is high. Thus, the combination of lansoprazole [L0233] or omeprazole [O0359] (as a proton pump inhibitor), amoxicillin [A2099] and metronidazole is used for the eradication of Helicobacter pylori.

References


PubMed Literature


TCIMAIL
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