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CAS RN: 23981-80-8 | Product Number: M1220
(±)-Naproxen
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Purity: >98.0%(GC)(T)
Synonyms:
- (±)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid
- (±)-2-(6-Methoxy-2-naphthyl)propionic Acid
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
£68.00
|
2 | ≥20 |
|
| 25G |
£266.00
|
2 | ≥20 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Specifications
| Appearance | White to Light red to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 154.0 to 158.0 °C |
| Solubility in Methanol | very faint turbidity |
Properties (reference)
| Melting Point | 157 °C |
| Solubility (soluble in) | Methanol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 245-969-2 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2918999090 |
Application
(±)-Naproxen: A Nonselective COX-1 and COX-2 Enzymes Inhibitor
(±)-Naproxen, a propionic acid derivative with a naphthalene nucleus, is a nonselective nonsteroidal anti-inflammatory drug (NSAID). Naproxen works by reversibly inhibiting both the COX-1 and COX-2 enzymes. The enantiomer (S)-naproxen [M1021] is a more active form than the (R)-naproxen which causes liver damage. Therefore, resolutions of (±)-naproxen and enantioselective syntheses of (S)-naproxen have been reported. (The product is for research purpose only.)
References
- Nonsteroidal antiinflammatory agents. I. 6-Substituted 2-naphthylacetic acids
- Design, synthesis, and evaluation of an improved enantioselective naproxen selector
- Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase
- Enantioselective esterification of racemic naproxen by lipases in organic solvent
- Chiral recognition ability of an (S)-naproxen-imprinted monolith by capillary electrochromatography
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