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CAS RN: 109581-93-3 | Product Number: M2258

Tacrolimus Monohydrate


Purity: >80.0%(HPLC)
Synonyms:
  • FK 506 Monohydrate
Documents:
10MG
£78.00
1   2  
50MG
£271.00
1   ≥20 

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Product Number M2258
Purity / Analysis Method >80.0%(HPLC)
Molecular Formula / Molecular Weight C__4__4H__6__9NO__1__2·H__2O = 822.05  
Physical State (20 deg.C) Solid
Storage Temperature <0°C
Condition to Avoid Heat Sensitive
CAS RN 109581-93-3
Related CAS RN 104987-11-3
Reaxys Registry Number 6265275
PubChem Substance ID 160871186
Merck Index (14) 9025
MDL Number

MFCD11045918

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 80.0 area%
Melting point 125.0 to 129.0 °C
Properties (reference)
Melting Point 127 °C
Solubility in water Insoluble
Solubility (soluble in) Acetone,Ethanol,Methanol
GHS
Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P270 : Do not eat, drink or smoke when using this product.
P264 : Wash skin thoroughly after handling.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
P405 : Store locked up.
Related Laws:
RTECS# KD4201200
Transport Information:
UN Number UN2811
Class 6.1
Packing Group III
HS Number 2934999090
Application
Tacrolimus: A Calcineurin Inhibitor with Immunosuppressive Properties

Tacrolimus, known as FK506, is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. Tacrolimus is practically insoluble in water, freely soluble in ethanol and DMF, and very soluble in methanol and chloroform. Tacrolimus inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that tacrolimus is inactive by itself and requires binding to an intracellular protein, FK506 binding protein-12 (FKBP-12), for activation in cells. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin (a calcium and calmodulin dependent protein phosphatase) is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent both T-lymphocyte signal transduction and IL-2 transcription. Cyclosporin A [C2408] also inhibits calcineurin but is less potent than tacrolimus. Tacrolimus is mainly metabolized by cytochrome P 450 IIIA (CYP3A) subfamilies. (The product is for research purpose only.)

References


PubMed Literature


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