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Published TCIMAIL newest issue No.198

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Published TCIMAIL newest issue No.198

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CAS RN: 59-67-6 | Product Number: N0082

Nicotinic Acid

Purity: >99.0%(T)(HPLC)

Synonyms:

Niacin
Pyridine-3-carboxylic Acid
Vitamin B₃

Product Documents:

Size	Unit Price	Belgium	Japan*	Quantity
25G	£16.00	Contact Us	≥100
500G	£30.00	7	≥100

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Almost white powder to crystal
Purity(HPLC)	min. 99.0 area%
Purity(Neutralization titration)	min. 99.0 %
Melting point	235.0 to 240.0 °C
Solubility in hot Water	almost transparency

Properties (reference)

Melting Point

238 °C

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H315 : Causes skin irritation. H319 : Causes serious eye irritation.
Precautionary Statements	P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention.

Related Laws:

EC Number	200-441-0
RTECS#	QT0525000

Transport Information:

HS Number

2936290000

Applications & Literature plus

Application

ニコチン酸の三つの面：ビタミンB3，抗高脂血症剤，および配位高分子化合物の架橋リガンド

Nicotinic acid has three faces. The first is vitamin B₃ (called niacin) which is required for the synthesis of coenzymes, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP).¹⁾ The second is an antilipemic agent which acts on the nicotinic acid receptor, inhibiting the enzyme triglyceride lipase.^2-4) The last is a bridging ligand for coordination polymers which is used for the synthesis of MOF/PCP.⁵⁾ For your reference, we have its analogue, acipimox [M2053]. (The product is for research purpose only.)

References

1)Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD⁺ precursor vitamins in human nutrition (a review)
- K. L. Bogan, C. Brenner, Annu. Rev. Nutr. 2008, 28, 115.
2)Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review
- L. A. Carlson, J. Internal Med. 2005, 258, 94.
3)Mechanism of action of niacin
- V. S. Kamanna, M. L. Kashyap, Am. J. Cardiol. 2008, 101, S20.
4)Nicotinic acid: pharmacological effects and mechanisms of action (a review)
- A. Gille, E. T. Bodor, K. Ahmed, S. Offermanns, Annu. Rev. Pharmacol. Toxicol. 2008, 48, 79.
5)Novel 3-D Framework Nickel(II) Complex with Azide, Nicotinic Acid, and Nicotinate(1-) as Coligands: Hydrothermal Synthesis, Structure, and Magnetic Properties
- F.-C. Liu, Y.-F. Zeng, J.-R. Li, X.-H. Bu, H.-J. Zhang, J. Ribas, Inorg. Chem. 2005, 44, 7298.

PubMed Literature

Documents

Organic Linker Molecules for Metal Organic Frameworks (MOFs)

Product Articles

Product Documents (Note: Some products will not have analytical charts available.)

Safety Data Sheet (SDS)

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Specifications

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Related Products

Nicotinic Acid [Matrix for MALDI-TOF/MS]

Product #	N1103
CAS RN	59-67-6
Purity / Analysis Method:	>99.5%(T)(HPLC)

Product Number	N0082
Purity / Analysis Method	>99.0%(T)(HPLC)
Molecular Formula / Molecular Weight	C__6H__5NO__2 = 123.11
Physical State (20 deg.C)	Solid
Storage Temperature	Room Temperature (Recommended in a cool and dark place, <15°C)
CAS RN	59-67-6
Reaxys Registry Number	109591
PubChem Substance ID	87573475
SDBS (AIST Spectral DB)	7944
Merck Index (14)	6525
MDL Number	MFCD00006391

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CAS RN: 59-67-6 | Product Number: N0082