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Published TCIMAIL newest issue No.198
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CAS RN: 55981-09-4 | Product Number: N1031
Nitazoxanide
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
- NTZ
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 200MG |
£34.00
|
Contact Us | 1 |
|
| 1G |
£107.00
|
1 | 2 |
|
| 5G |
£342.00
|
2 | 29 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product is a sample for RUO (research use only). Do not use this product for any purpose other than testing and research.
| Product Number | N1031 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__2H__9N__3O__5S = 307.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 55981-09-4 |
| Reaxys Registry Number | 1225475 |
| PubChem Substance ID | 354333058 |
| Merck Index (14) | 6567 |
| MDL Number | MFCD00416599 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 198.0 to 202.0 °C |
Properties (reference)
| Melting Point | 200 °C |
| Maximum Absorption Wavelength | 416 nm (Phosphate buffer sol.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| EC Number | 259-931-8 |
| RTECS# | VN7830000 |
Transport Information:
| HS Number | 2934100090 |
Application
Nitazoxanide: A Thiazolide Antiprotozoal and Antiviral Agent
Nitazoxanide is originally developed as a thiazolide antiprotozoal agent that shows excellent in vitro activity against a variety of microorganisms, including a broad range of protozoa and helminths. Nitazoxanide is a prodrug, and following oral administration in animals, nitazoxanide is rapidly hydrolyzed to an active metabolite, tizoxanide [T3862] (desacetyl-nitazoxanide) by esterase. The antiprotozoal activity of tizoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Recently, antiviral activity of nitazoxanide against a broad range of other RNA and DNA viruses such as hepatitis B virus, hepatitis C virus and influenza virus has been recognized in in vitro systems. Nitazoxanide is synergistic with neuraminidase inhibitors, and also inhibits the replication of a broad range of viruses. (The product is for research purpose only.)
References
- In vitro evaluation of activities of nitazoxanide and tizoxanide against anaerobes and aerobic organisms
- Efficacy of nitazoxanide against Cryptosporidium parvum in cell culture and in animal models
- Nitazoxanide: a new thiazolide antiparasitic agent (a review)
- Nitazoxanide a review of its use in the treatment of gastrointestinal infections
- Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
- Nitazoxanide: A first-in-class broad-spectrum antiviral agent (a review)
PubMed Literature
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