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CAS RN: 7240-38-2 | Product Number: O0353

Oxacillin Sodium Salt Monohydrate


Purity: >95.0%(T)
Synonyms:
Documents:
1G
£20.00
3   ≥20 
5G
£61.00
1   1  
25G
£123.00
1   ≥20 

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Note:

This product has not been tested for potency and is guaranteed for chemical purity.

Product Number O0353
Purity / Analysis Method >95.0%(T)
Molecular Formula / Molecular Weight C__1__9H__1__8N__3NaO__5S·H__2O = 441.44  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Hygroscopic,Heat Sensitive
CAS RN 7240-38-2
Related CAS RN 66-79-5&1173-88-2
Reaxys Registry Number 4287093
PubChem Substance ID 87560310
Merck Index (14) 6904
MDL Number

MFCD00167146

Specifications
Appearance White to Almost white powder to crystal
Purity(HPLC) min. 98.0 area%
Purity(Volumetric Analysis) min. 95.0 %
Specific rotation [a]20/D +200.0 to +210.0 deg(C=1, H2O)(calcd.on anh.substance)
Water 3.5 to 5.0 %
Properties (reference)
Melting Point 188 °C(dec.)
Specific Rotation 205° (C=1,H2O)
GHS
Related Laws:
Transport Information:
HS Number 2941100000
Application
Oxacillin Sodium: A β-Lactamase-Resistant Penicillin

Oxacillin sodium, an isoxazolyl penicillin, is chemically synthesized from 6-APA [A0800] and [M2996]. Oxacillin has activity against Gram-positive bacteria, but less activity against Gram-negative bacteria, the same as penicillin G [P1770] [P1772]. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Meanwhile, oxacillin, cloxacillin [C2244] and methicillin are resistant to the enzymes (β-lactamases) which produced by bacteria that destroy β-lactam antibiotics like penicillins and cephalosporins, due to theirs large side-chain, which does not allow the β-lactamases to bind. However, with the widespread use of oxacillin, antibiotic-resistant strains called oxacillin-resistant Staphylococcus aureus (ORSA) have become increasingly prevalent worldwide.

References


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