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CAS RN: 219580-11-7 | Product Number: P2474

PD 173074


Purity: >95.0%(HPLC)
Synonyms:
  • 1-(tert-Butyl)-3-[7-[[4-(diethylamino)butyl]amino]-3-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-yl]urea
Documents:
10MG
£45.00
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50MG
£145.00
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Product Number P2474
Purity / Analysis Method >95.0%(HPLC)
Molecular Formula / Molecular Weight C__2__8H__4__1N__7O__3 = 523.68 
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Condition to Avoid Heat Sensitive
CAS RN 219580-11-7
Reaxys Registry Number 10130688
PubChem Substance ID 354335228
MDL Number

MFCD08705327

Specifications
Appearance White to Yellow to Orange powder to crystal
Purity(HPLC) min. 95.0 area%
Properties (reference)
Melting Point 86 °C
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H315 : Causes skin irritation.
H319 : Causes serious eye irritation.
Precautionary Statements P264 : Wash skin thoroughly after handling.
P280 : Wear protective gloves/ eye protection/ face protection.
P302 + P352 : IF ON SKIN: Wash with plenty of water.
P337 + P313 : If eye irritation persists: Get medical advice/ attention.
P362 + P364 : Take off contaminated clothing and wash it before reuse.
P332 + P313 : If skin irritation occurs: Get medical advice/ attention.
Related Laws:
Transport Information:
HS Number 2933998090
Application
Research on regenerative medicine

PD 173074 inhibits the differentiation of mouse and human embryo stem cells1,2) and human induced pluripotent stem cells.3)

References


Application
PD173074: A Selective VEGFR and FGFR Inhibitor

PD173074 is a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, and also a selective fibroblast growth factor receptor (FGFR) inhibitor. VEGF is a signalling protein that induces angiogenesis and endothelial cell proliferation and it plays an important role in regulating vasculogenesis. FGF is a carrier protein that regulates important biological processes including cell proliferation and differentiation during development and tissue repair. The human FGFR reportedly comprises of four family members, FGFR1, FGFR2, FGFR3 and FGFR4. Recently, the anti-tumor activities of PD173074, targeted neoangiogenesis and mitogenesis, have been reported. (The product is for research purpose only.)

References


PubMed Literature


Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Other Documents

Life Science
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