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Published TCIMAIL newest issue No.199
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CAS RN: 147098-20-2 | Product Number: R0180
Rosuvastatin Calcium
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Purity: >95.0%(HPLC)(N)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
£70.00
|
7 | ≥100 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | R0180 |
Purity / Analysis Method 
|
>95.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__4__4H__5__4CaF__2N__6O__1__2S__2 = 1,001.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 147098-20-2 |
| Related CAS RN
|
287714-41-4 |
| Reaxys Registry Number | 7740139 |
| PubChem Substance ID | 253661249 |
| Merck Index (14) | 8270 |
| MDL Number | MFCD04112702 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(with Total Nitrogen) | min. 95.0 % |
| Purity(Chelometric Titration) | min. 90.0 % |
| Specific rotation [a]20/D | -7.0 to -10.0 deg(C=1, CHCL3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 160 °C |
| Specific Rotation | -8° (C=1,CHCl3) |
| Maximum Absorption Wavelength | 243 nm (Phosphate buffer sol.) |
GHS
Related Laws:
| RTECS# | MJ9675070 |
Transport Information:
| HS Number | 2935909099 |
Application
VSV-G lentivirus vector transduction enhancer
Rosuvastatin enhances VSV-G lentiviral transduction of NK Cells.1)
References
- 1) Rosuvastatin enhances VSV-G lentiviral transduction of NK cells via upregulation of the low-density lipoprotein receptor
Application
Rosuvastatin Calcium: A Strong HMG-Coa Reductase Inhibitor (a Strong Statin)
Rosuvastatin calcium is a 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase inhibitor (statin). Compared with most other statins, rosuvastatin possesses a greater number of binding interactions with HMG-CoA reductase and exhibits greater potency in inhibiting enzyme activity and cholesterol synthesis in hepatic cells than other statins. Rosuvastatin is relatively hydrophilic, similar in this respect to pravastatin [P1796]. Rosuvastatin has one of the longest terminal half-life of the statins and is only minimally metabolized by the cytochrome P 450 (CYP 450) enzyme system with no significant involvement of the 3A4 (CYP3A4) enzyme.
References
- Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (a review)
- A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin
- Structural mechanism for statin inhibition of HMG-CoA reductase
- Determination of simvastatin, pravastatin sodium and rosuvastatin calcium in tablet dosage forms by HPTLC
- A new improved RP-HPLC method for assay of rosuvastatin calcium in tablets
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
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