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CAS RN: 1421-86-9 | Product Number: S0257
Strychnine Hydrochloride
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Purity: >98.0%(T)
Synonyms:
Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
£91.00
|
Contact Us | 7 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Note:
Previously this product had been labeled as a hydrate form both in product name and molecular formula. The hydrate form had no exclusive CAS RN and used to share the same CAS RN as the anhydrous form.
To avoid any misleading information and since moisture in product is considered as an impurity, we have decided to remove the term 'Hydrate' from product name and 'xH2O' from the molecular formula for such products.
Please use it at ease since there is no difference in product quality, even if you see the previous indications on a part of label.
| Product Number | S0257 |
| Purity / Analysis Method | >98.0%(T) |
| Molecular Formula / Molecular Weight | C__2__1H__2__2N__2O__2·HCl = 370.88 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 1421-86-9 |
| Reaxys Registry Number | 4927442 |
| PubChem Substance ID | 87575783 |
| Merck Index (14) | 8855 |
| MDL Number | MFCD00058174 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 96.0 area% |
| Purity(Argentometric Titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | -27.0 to -30.0 deg(C=1, H2O) |
| Water | max. 9.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 295 °C |
| Specific Rotation | -29° (C=1,H2O) |
| Solubility in water | Slightly soluble |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 + H330 : Fatal if swallowed or if inhaled. H410 : Very toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P273 : Avoid release to the environment. P260 : Do not breathe dust. P391 : Collect spillage. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P304 + P340 + P310 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/doctor. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| EC Number | 215-826-9 |
| RTECS# | WL2430000 |
Transport Information:
| UN Number | UN1692 |
| Class | 6.1 |
| Packing Group | I |
| HS Number | 2939799090 |
Application
Strychnine: An Indole Alkaloid with Antagonistic Activity toward Glycine and Acetylcholine Receptors
Strychnine [S0249] is an indole alkaloid obtained from the seeds and bark of Strychnos nux-vomica, has been used as a rodenticide for more than a century. Glycine is an inhibitory transmitter to motor neurons and interneurons in the spinal cord. Strychnine is a neurotoxin which acts as an antagonist of glycine and acetylcholine receptors, resulting in disinhibition of motor neurons in the spinal cord.1,2) In addition, strychnine has been a target compound for total synthesis since it was first synthesized by the group of R. B. Woodward in 1954.3,4) Strychnine is poorly soluble in water, but its sulfate [S0094], nitrate [S0093] and hydrochloride [S0257] are moderately soluble in water. (The product is for research purpose only.)
References
- 1) The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors
- 2) Inhibitory glycine receptors: an update (a review)
- 3) Synthesis of Strychnine (a review)
- 4) Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis
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