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Published TCIMAIL newest issue No.198
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CAS RN: 52-01-7 | Product Number: S0260
Spironolactone
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Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
£27.00
|
2 | 2 |
|
| 5G |
£86.00
|
Contact Us | 12 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | S0260 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__3__2O__4S = 416.58 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 52-01-7 |
| Reaxys Registry Number | 57767 |
| PubChem Substance ID | 87575785 |
| SDBS (AIST Spectral DB) | 11014 |
| Merck Index (14) | 8760 |
| MDL Number | MFCD00082250 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(UV-vis method) | min. 95.0 % |
| Specific rotation [a]20/D | -34.0 to -38.0 deg(C=1, CHCl3) |
| Solubility in EtOH | very faint turbidity |
Properties (reference)
| Specific Rotation | -36° (C=1,CHCl3) |
GHS
Related Laws:
| EC Number | 200-133-6 |
| RTECS# | TU4725000 |
Transport Information:
| HS Number | 2932209090 |
Application
Spironolactone: An Aldosterone Receptor Antagonist
Spironolactone is an aldosterone (a mineralocorticoid) receptor antagonist. Spironolactone binds to the receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule, and causes increased amounts of sodium and water to be excreted, while potassium is retained. By this mechanisms of action, spironolactone acts both as a diuretic and as an antihypertensive agent. (The product is for research purpose only.)
References
- Localization of Physiological Receptor Sites for Aldosterone in the Bladder of the Toad, Bufo tnarinus
- Blocking the renal electrolyte effects of mineralocorticoids with an orally active steroidal spirolactone
- Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology (a review)
- Pharmacokinetics and Pharmacodynamics of Mineralocorticoid Blocking Agents and their Effects on Potassium Homeostasis (a review)
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